Evidence map›Paper›PMID 41981591›Full record

ArticleJournal of nanobiotechnology2026

Exosome-mediated Piezo1 activation in 3D-printed titanium scaffolds promotes repair of femoral head osteonecrosis.

Yang Yu, Zhongyin Ji, Hongjun Xu, Mingyang Ma, Zhaojing Yin, Yiyang Du, Tao Zhang, Guiguan Wang, Feng Tian, Sen Liu and 2 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Yang Yu *Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People's Republic of China.
Zhongyin Ji *Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People's Republic of China.
Hongjun XuDepartment of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People's Republic of China.
Mingyang MaDepartment of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People's Republic of China.
Zhaojing YinSchool of Medicine, Tsinghua University, Beijing, 100084, People's Republic of China.
Yiyang DuSchool of Medicine, Tsinghua University, Beijing, 100084, People's Republic of China.
Tao ZhangBeijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China.
Guiguan WangDepartment of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People's Republic of China.
Feng TianBeijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China.
Sen LiuDepartment of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People's Republic of China. liusen@pumch.cn.
Jiajia XueBeijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China. jiajiaxue@mail.buct.edu.cn.
Wenwei QianDepartment of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People's Republic of China. qianww@pumch.cn.

Funding

National Natural Science Foundation of China No. 82372410 and 81972046the National High Level Hospital Clinical Research Funding 2022-PUMCH-B-001
6 · The paper itself

Abstract

Osteonecrosis of the femoral head (ONFH) is a debilitating bone disorder characterized by ischemic degeneration with limited therapeutic options. Piezo1, a mechanosensitive ion channel, transduces physical stimuli into intracellular signals regulating osteogenesis and angiogenesis. Here, we developed a 3D-printed Ti6Al4V scaffold conformally coated with photocrosslinked hyaluronic acid hydrogel that retains and releases Piezo1-engineered exosomes (P-Exos), forming a hybrid construct (P-Exos@HAMA/Ti) with cancellous-bone-like stiffness and sustained bioactivity. In vitro studies demonstrated that P-Exos enhanced BMSC viability, migration, and osteogenic differentiation (ALP/ARS; Runx2, Osterix, OCN) while promoting endothelial proliferation and network formation (CD31, VEGFA). RNA-seq and mechanistic validation revealed Ca

Indexed as

ExosomesFemur Head NecrosisIon ChannelsTissue ScaffoldsTitaniumAnimalsCell DifferentiationHumansHyaluronic AcidHydrogelsMaleMesenchymal Stem CellsOsteogenesisPrinting, Three-DimensionalRatsRats, Sprague-DawleyHyaluronic AcidHydrogelsIon ChannelsPIEZO1 protein, humanTitaniumYAP-Signaling Proteins3D printing scaffoldsOsteonecrosis of the femoral head (ONFH)Piezo1-engineered exosomesYAP1/β-catenin signaling pathway

Identifiers

PMID41981591
PMCPMC13200330

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.