ArticleBMC pulmonary medicine2026
Age-related differences in adherence to inhaled corticosteroids among adult patients with asthma: a national cohort study in South Korea.
Article in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundUnderstanding age-related differences in adherence to inhaled corticosteroids (ICSs) is crucial to optimize asthma management.
objectivesTo explore differences in adherence levels among different age groups of adult patients with asthma in South Korea from January 2016 to December 2020.
methodsWe performed a population-based cohort study using data from South Korea’s National Health Insurance Service, including individuals aged 18 to 79 who began using ICS between 2016 and 2020. Adults with asthma were categorized into three age groups: young adults (18–39 years of age), middle-aged adults (40–59 years of age), and older adults (60–79 years of age). The primary outcomes were medication adherence, indicated by the proportion of days covered (PDC), and persistence. Additionally, asthma outcomes, including the risk of asthma exacerbation and pneumonia, were analyzed.
resultsAmong the 15,367 included patients, 4,237 were young adults, 6,132 were middle-aged adults, and 4,998 were older adults. Older adults had a significantly higher PDC (0.56 ± 0.20) than middle-aged (0.53 ± 0.20) and young adults (0.52 ± 0.20; P < .001). Additionally, older adults had a 29.4% lower risk of discontinuation compared with young adults (adjusted hazard ratio [aHR], 0.706; 95% confidence interval [CI], 0.667–0.747; P < .001) and a 13.4% lower risk compared with middle-aged adults (aHR, 0.866; 95% CI, 0.821–0.913; P < .001). Despite higher medication adherence, older adults experienced a higher risk of severe asthma exacerbations (aHR, 1.848; 95% CI, 1.568–2.178; P < .001) than young adults.
conclusionOlder adults demonstrated better adherence to ICS-containing inhalers but also had higher risks of severe exacerbations and pneumonia, highlighting the necessity for age-specific management strategies.
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