ArticleBMC emergency medicine2026
The prognostic significance of the mechanism of mild to moderate alkalemia at emergency department admission.
Article in BMC emergency medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Severe alkalemia in the emergency department : Acid-base patterns, clinical presentation and short-term outcomes in hospitalized patients.Wiener klinische Wochenschrift · 2026Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPaucity of evidence exists as to the prognostic significance of mild to moderate alkalemia upon presentation to the emergency department (ED).
methodsPatients presenting to the ED of one tertiary hospital over the last 24 years were included in this retrospective cohort study if the serum pH drawn within 3 h of the initial presentation was 7.45–7.55. Alkalemia was defined as primarily metabolic (PM) if PCO2≥35mmHg, and primarily respiratory (PR) if HCO3≤24mEq/L - otherwise, the etiology was considered to be mixed and the case was excluded from this analysis. The primary outcome was 30 days mortality, analysed by Cox’s regression.
resultsOf 25,884 patients included in the final analysis, 14,802 (47.4%) were PM and 11,082 (35.4%) PR. Adjusted for age, comorbidities, severity scores, potassium derangements, and year of admission, PR was associated with increased 30-day mortality (aHR 1.21, 95% CI [1.12–1.32]). The association of higher degree of alkalemia with increased mortality was significant only in the PM group (p < 0.001).
conclusionsThe etiology of alkalemia (PR vs. PM) could provide important prognostication in the ED, even in mild to moderate cases.
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