Evidence map›Paper›PMID 41981450›Full record

ArticleJournal of nanobiotechnology2026

Multifunctional ions/drugs co-delivering nanocomposite hydrogel orchestrates neuro-osteogenic microenvironment for boosting osteoporotic osseointegration.

Shengyang Jin, Ismat Ullah, Zhaowei Chen, Yuwei Ge, Tao Feng, Yan Yang, Qi Yan, Jinning Wang, Dawei Song, Zicheng Deng and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shengyang Jin *Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Ismat Ullah *Depatment of Physics, Federal Urdu University of Arts, Science and Technology, Islamabad, 44000, Pakistan.
Zhaowei Chen *Department of Orthopaedics, Suzhou Dushu Lake Hospital, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou, 215000, China.
Yuwei GeDepartment of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.
Tao FengDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Yan YangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Qi YanDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Jinning WangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Dawei SongDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Zicheng DengDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Zhenfei HuangDepartment of Orthopaedics, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Wei CuiDepartment of Orthopedics, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, 214000, China. cw870608@163.com.
Hui SunDepartment of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. sunshine20002000@126.com.
Junjie NiuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. niujunjie1129@suda.edu.cn.
Liang YangDepartment of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. ly666@shsmu.edu.cn.

Funding

Entrepreneurship and Innovation Doctoral Program of Jiangsu Province JSSCBS20230503National Natural Science Foundation of China 82202697National Natural Science Foundation of China 82302680National Natural Science Foundation of China 82472426Suzhou Basic Research Pilot Program SSD2024048Technology Innovation on Medicine and Health of Suzhou Science and Technology Bureau SKY2023147
6 · The paper itself

Abstract

With population aging, the incidence of osteoporosis continuously elevates worldwide, resulting in increased fracture risks and clinical demand for orthopedic fixation. However, under osteoporotic conditions, the stability and longevity of implants are severely compromised by the pathological microenvironment, thus developing effective therapeutic interventions to achieve successful osteoporotic osseointegration remains a critical challenge in the regenerative medicine field. Herein, the parathyroid hormone (PTH) is encapsulated in Sr

Indexed as

HydrogelsNanocompositesOsseointegrationOsteogenesisOsteoporosisAnimalsDrug Delivery SystemsIonsMesenchymal Stem CellsParathyroid HormonePorosityRatsRats, Sprague-DawleySilicon DioxideHydrogelsIonsParathyroid HormoneSilicon DioxideDrug deliveryInnervationIon dopingNanocomposite hydrogelOsteoporotic osseointegration

Identifiers

PMID41981450
PMCPMC13200440

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.