ArticleZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery2026
[Effect of composite graphene-protein hydrogels on neural regeneration after spinal cord injury in rats].
Article in Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the role of composite graphene-protein hydrogels in repairing spinal cord injury (SCI) and promoting neural regeneration in rats. Methods: A composite graphene-protein hydrogel was prepared using the radical copolymerization method. Its physical properties, including adhesion, were evaluated through shear testing, and cytotoxicity was assessed using the MTT assay. Twenty-four adult female Sprague-Dawley rats were randomly divided into four groups: sham surgery, injury, hydrogel, and hydrogel+graphene groups (6 rats per group). The sham surgery group only exposed the T Results: Shear testing and MTT assays demonstrated that the composite graphene-protein hydrogels exhibited excellent underwater adhesion and biocompatibility. All rats in each group survived until the end of the experiment. During 12-week postoperative period, the BBB scores in the hydrogel and hydrogel+graphene groups showed a sustained upward trend over time ( Conclusion: The composite graphene-protein hydrogels effectively repairs SCI in rats by significantly inhibiting glial scar formation at the injury site, promoting 5-HT-positive axonal regeneration, and improving post-injury neurophysiological function and hindlimb motor recovery. It represents a spinal cord repair material with potential clinical application value.
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