Evidence map›Paper›PMID 41981439›Full record

Trial reportZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery2026

[Effectiveness of lymphaticovenular anastomosis combined with perioperative targeted drainage in treatment of secondary lower limb lymphedema: a prospective randomized trial].

Xiaoyan Wang, Jing Du, Xiaomao Zhang, Shaoying Lu, Liang Zhao, Hui Cai

Abstract readRandomized Controlled TrialEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Xiaoyan WangDepartment of Vascular Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Shaanxi, 710089, P. R. China.
Jing DuDepartment of Traditional Chinese Medicine Rehabilitation, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Shaanxi, 710089, P. R. China.
Xiaomao ZhangDepartment of Vascular Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Shaanxi, 710089, P. R. China.
Shaoying LuDepartment of Vascular Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Shaanxi, 710089, P. R. China.
Liang ZhaoDepartment of Vascular Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Shaanxi, 710089, P. R. China.
Hui CaiDepartment of Vascular Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Shaanxi, 710089, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the effectiveness of lymphaticovenular anastomosis (LVA) combined with perioperative targeted multi-layer circular lymphatic drainage in the treatment of secondary lower limb lymphedema using a prospective randomized controlled trial. Methods: In a prospective randomized controlled trial, 80 patients with secondary lower limb lymphedema admitted between January 2023 and September 2025 were initially enrolled and allocated to either the trial group (LVA+targeted lymphatic drainage) or the control group (LVA+conventional lymphatic drainage), 40 in each group. After 2 dropouts in the control group, 78 patients (40 in the trial group, 38 in the control group) were included for analysis. There was no significant difference in the baseline data ( Results: All patients were followed up 3-12 months (mean, 6.5 months). Postoperatively, the trial group demonstrated significantly better functional recovery and a superior trend in lower limb circumference reduction at all time points compared to the control group ( Conclusion: The application of targeted multi-layer circular lymphatic drainage during the perioperative period of LVA is safe and effective. It significantly promotes lower limb circumference reduction and functional recovery without increasing the risk of complications.

Indexed as

Anastomosis, SurgicalDrainageLower ExtremityLymphatic VesselsLymphedemaAdultAgedFemaleHumansInterleukin-6MaleMiddle AgedProspective StudiesTransforming Growth Factor beta1Treatment OutcomeVascular Endothelial Growth Factor CInterleukin-6Transforming Growth Factor beta1Vascular Endothelial Growth Factor Ceffectiveness analysislymphaticovenular anastomosisrandomized controlled trialSecondary lymphedematargeted drainage

Identifiers

PMID41981439
PMCPMC13096818

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.