Evidence map›Paper›PMID 41981426›Full record

ArticleZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery2026

[Differential analysis of gut microbiome in patients with periprosthetic joint infection, aseptic failure, and osteoarthritis].

Kari Muzhabaier, Yicheng Li, Fei Wang, Xiaobin Guo, Quan Chen, Xiaogang Zhang, Li Cao

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Kari MuzhabaierDepartment of Orthopedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China.
Yicheng LiDepartment of Orthopedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China.
Fei WangDepartment of Orthopedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China.
Xiaobin GuoDepartment of Orthopedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China.
Quan ChenDepartment of Orthopedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China.
Xiaogang ZhangDepartment of Orthopedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China.
Li CaoDepartment of Orthopedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To explore the differences in gut microbiota diversity and structural characteristics among patients with periprosthetic joint infection (PJI), aseptic failure (AF), and osteoarthritis (OA), and to analyze the association between gut microbiota dysbiosis and the occurrence of PJI, thereby providing a new theoretical basis for elucidating the pathogenesis and treatment strategies of PJI in clinical practice. Methods: The study enrolled patients with PJI and AF admitted between February 2024 and December 2024, as well as OA patients admitted in February 2024. A total of 52 PJI patients, 19 AF patients, and 29 OA patients who met the selection criteria were included in the analysis. Significant differences were observed among the three groups in terms of gender, age, surgical site, preoperative C-reactive protein levels, and erythrocyte sedimentation rate ( Results: Analysis of gut microbiota diversity showed that the preoperative α-diversity indices (ACE index, Chao1 index, Shannon index, Simpson index, and observed_species index) in the PJI group were significantly lower than those in AF group and OA group ( Conclusion: Patients with PJI exhibited a gut microbiota profile characterized by reduced diversity and enrichment of opportunistic pathogens. Postoperative antibiotic treatment further aggravated this dysbiosis, providing new clinical insights into the role of gut microbiota imbalance in the pathogenesis and progression of PJI.

Indexed as

DysbiosisGastrointestinal MicrobiomeOsteoarthritisProsthesis FailureProsthesis-Related InfectionsAgedArthroplasty, Replacement, HipArthroplasty, Replacement, KneeBacteriaFecesFemaleHumansMaleMiddle Agedaseptic failuregut microbiota dysbiosismetagenomics next-generation sequencingosteoarthritisPeriprosthetic joint infection

Identifiers

PMID41981426
PMCPMC13096846

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.