Evidence map›Paper›PMID 41981423›Full record

ArticleZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery2026

[Efficacy and safety of emergency administration of tranexamic acid in elderly patients with intertrochanteric femoral fractures].

Chen Rui, Guangchun Dai, Wenbin Fan, Shaoyang Zhou, Chuwei Tian, Liu Shi, Tian Xie, Cheng Zhang, Xiangxu Chen, Hui Chen and 1 more

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Chen RuiDepartment of Orthopedics, Zhongda Hospital Affiliated to Southeast University, Nanjing Jiangsu, 210009, P. R. China.
Guangchun DaiDepartment of Orthopedics, Zhongda Hospital Affiliated to Southeast University, Nanjing Jiangsu, 210009, P. R. China.
Wenbin FanDepartment of Orthopedics, Zhongda Hospital Affiliated to Southeast University, Nanjing Jiangsu, 210009, P. R. China.
Shaoyang ZhouDepartment of Orthopedics, Zhongda Hospital Affiliated to Southeast University, Nanjing Jiangsu, 210009, P. R. China.
Chuwei TianDepartment of Orthopedics, Zhongda Hospital Affiliated to Southeast University, Nanjing Jiangsu, 210009, P. R. China.
Liu ShiDepartment of Orthopedics, Zhongda Hospital Affiliated to Southeast University, Nanjing Jiangsu, 210009, P. R. China.
Tian XieDepartment of Orthopedics, Zhongda Hospital Affiliated to Southeast University, Nanjing Jiangsu, 210009, P. R. China.
Cheng ZhangDepartment of Orthopedics, Zhongda Hospital Affiliated to Southeast University, Nanjing Jiangsu, 210009, P. R. China.
Xiangxu ChenDepartment of Orthopedics, Zhongda Hospital Affiliated to Southeast University, Nanjing Jiangsu, 210009, P. R. China.
Hui ChenDepartment of Orthopedics, Zhongda Hospital Affiliated to Southeast University, Nanjing Jiangsu, 210009, P. R. China.
Yunfeng RuiDepartment of Orthopedics, Zhongda Hospital Affiliated to Southeast University, Nanjing Jiangsu, 210009, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the efficacy and safety of emergency administration of tranexamic acid (TXA) in reducing perioperative blood loss and blood transfusion rate in elderly patients with intertrochanteric femoral fractures. Methods: A retrospective analysis was conducted on the clinical data of 102 elderly patients with intertrochanteric femoral fractures who were admitted between October 2023 and May 2025 and met the selection criteria. Patients were divided into two groups based on whether TXA was administered in the emergency department: the TXA group (patients received a single intravenous infusion of 1 g TXA immediately upon emergency admission, Results: There was no significant difference in operation time between the two groups ( Conclusion: Elderly patients with intertrochanteric femoral fractures experience significant blood loss due to initial trauma. Emergency administration of TXA can reduce trauma-induced preoperative HBL, perioperative TBL, and in-hospital blood transfusion rate without increasing the incidence of thromboembolic events, thus proving safe and effective.

Indexed as

Antifibrinolytic AgentsBlood Loss, SurgicalHip FracturesTranexamic AcidAgedAged, 80 and overBlood TransfusionFemaleFracture Fixation, InternalHemoglobinsHumansInfusions, IntravenousMalePostoperative HemorrhageProximal Femoral FracturesRetrospective StudiesAntifibrinolytic AgentsHemoglobinsTranexamic Acidemergencyhidden blood lossintertrochanteric femoral fracturesThe elderlytranexamic acid

Identifiers

PMID41981423
PMCPMC13096838

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.