Evidence map›Paper›PMID 41981337›Full record

ArticleNature neuroscience2026

White matter pathways mediating dorsolateral prefrontal TMS therapy for depression.

Caio Seguin, Sina Mansour L, Richard F Betzel, Evgeny J Chumin, Maria Grazia Puxeddu, Jinglei Lv, Linden Parkes, Paul B Fitzgerald, Robin F H Cash, Andrew Zalesky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. How indirect is too indirect? Structural pathways to the sgACC and the antidepressant response to TMS.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Caio SeguinDepartment of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia. caio.seguin@unimelb.edu.au.ORCID http://orcid.org/0000-0001-9384-6336
Sina Mansour LDepartment of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-5695-5696
Richard F BetzelDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-9200-1681
Evgeny J ChuminCenter for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA.
Maria Grazia PuxedduDepartment of Computer, Control, and Management Engineering, University of Rome La Sapienza, Rome, Italy.ORCID http://orcid.org/0000-0001-8725-465X
Jinglei LvSydney Medical School, School of Biomedical Engineering, and Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-4906-2646
Linden ParkesDepartment of Psychiatry, Brain Health Institute, Rutgers University, Piscataway, NJ, USA.ORCID http://orcid.org/0000-0002-9329-7207
Paul B FitzgeraldSchool of Medicine and Psychology, College of Health and Medicine, The Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0003-4217-8096
Robin F H Cash *Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-2612-9470
Andrew Zalesky *Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-2298-9908

Funding

Peripheral and Central Biomarkers of Alzheimer's Disease in Diverse CohortsU19AG074879 · NIA · MAYO CLINIC JACKSONVILLE · PI Minerva Maria Carrasquillo · 2023 to 2026
$42.0M
Research Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1M
KBASE2: Korean Brain Aging Study, Longitudinal Endophenotypes and Systems BiologyU01AG072177 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI LEE, DONG YOUNG, NHO, KWANGSIK TIMOTHY · 2021 to 2025
$11.2M
Training Grant on Alzheimer's Disease and ADRD at Indiana UniversityT32AG071444 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI GARY E. LANDRETH, Bruce T Lamb · 2021 to 2026
$2.8M
Discovering prognostic neuroimaging biomarkers of the psychosis spectrum using network control theoryR00MH127296 · NIMH · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI PARKES, LINDEN · 2023 to 2025
$747k
NIA NIH HHS L30 AG089730NIA NIH HHS P30 AG072976NIA NIH HHS T32 AG071444NIA NIH HHS U01 AG072177NIA NIH HHS U19 AG074879NIMH NIH HHS R00 MH127296
6 · The paper itself

Abstract

We use connectome modeling to map polysynaptic fiber pathways underlying transcranial magnetic stimulation (TMS) therapy for depression. We propose putative cortical and subcortical routes that connect stimulation sites in the dorsolateral prefrontal cortex to the subgenual cingulate cortex via intermediate regions. Here we show that route length explains both TMS treatment response in two independent patient cohorts and the clinical efficacy of functional magnetic resonance imaging-guided TMS targeting. Our results illuminate the neuroanatomical basis of TMS therapy for depression.

Indexed as

DepressionDorsolateral Prefrontal CortexPrefrontal CortexTranscranial Magnetic StimulationWhite MatterAdultConnectomeFemaleHumansMagnetic Resonance ImagingMaleNeural Pathways

Identifiers

PMID41981337
PMCPMC13637561

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.