ArticleNature neuroscience2026
HSV-1 strain H129 co-opts neuronal synaptic transmission machinery for its transsynaptic spread.
Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- XPO1 coordinates human cytomegalovirus maturation by modulating genome encapsidation and secondary envelopment.Cell insight · 2026Article
- Rabies Virus Glycoprotein G Variation Is Associated with Neurovirulence and Reduced Vamp2 Abundance in a Mouse Model of Direct CNS Infection.Veterinary sciences · 2026Article
- HSV-1 infections of the prefrontal cortex: regional vulnerability, cellular mechanisms, and neurocognitive consequences.Frontiers in cellular neuroscience · 2026Review
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Authors and funding
18 authors.
Funding
Abstract
The H129 strain (H129) of neurotropic herpes simplex virus-1 (HSV-1) is the only known HSV-1 strain that spreads transneuronally in a predominantly anterograde direction, leading to wide use for anterograde tracing in neural circuit mapping. However, it remains unclear whether H129 spreads in a synapse-specific manner or what mechanisms underlie its transmission. Here a microfluidic culture system for primary mouse cortical neurons and several engineered tool viruses were used to visualize the synapse-specific transmission of H129. We show that H129 particles are packaged into 'virion vesicles' that exploit the molecular machinery of Ca
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