Evidence map›Paper›PMID 41981316›Full record

SynthesisNature genetics2026

Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting.

Marlena Fejzo, Xinran Wang, Qing Tan, Julia Zöllner, Natàlia Pujol-Gualdo, Triin Laisk, Estonian Biobank Research Team, Sarah Finer, David A van Heel, Genes & Health Research Team and 24 more

Erratum issuedAbstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Nature genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

34 authors.

Marlena FejzoDepartment of Population and Public Health Science, Center for Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA. marlena.fejzo@med.usc.edu.ORCID http://orcid.org/0000-0001-6800-687X
Xinran WangDepartment of Population and Public Health Science, Center for Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-9670-3939
Qing TanDepartment of Population and Public Health Science, Center for Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-3272-2799
Julia ZöllnerUCL EGA Institute for Women's Health, University College London, London, UK.ORCID http://orcid.org/0000-0002-9072-9131
Natàlia Pujol-GualdoInstitute of Genomics, Estonian Genome Centre, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0001-6428-8427
Triin LaiskInstitute of Genomics, Estonian Genome Centre, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0003-1501-9030
Estonian Biobank Research Team
Sarah FinerWolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-2684-4653
David A van HeelBlizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-0637-2265
Genes & Health Research Team
Ben BrumptonDepartment of Public Health and Nursing, NTNU, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0002-3058-1059
Laxmi BhattaDepartment of Public Health and Nursing, NTNU, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.
Kristian HveemDepartment of Public Health and Nursing, NTNU, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.
Elizabeth A JasperDepartment of Obstetrics and Gynecology, Division of Quantitative and Clinical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Digna R Velez EdwardsDepartment of Obstetrics and Gynecology, Division of Quantitative and Clinical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5293-0056
Jacklyn N HellwegeDepartment of Obstetrics and Gynecology, Division of Quantitative and Clinical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-7479-0920
Todd EdwardsDepartment of Obstetrics and Gynecology, Division of Quantitative and Clinical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-4318-6119
Gail P JarvikDepartments of Medicine (Medical Genetics) and Genome Sciences, University of Washington Medical Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6710-8708
Yuan LuoDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-0195-7456
Atlas KhanDepartment of Medicine, Division of Nephrology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-6651-2725
Kimber MacGibbonHyperemesis Education and Research Foundation, Clackamas, OR, USA.ORCID http://orcid.org/0000-0002-6534-3114
Yuan GaoKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.
Gaoxiang GeKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0003-3189-8928
Inna AverbukhDepartment of Pathology, Stanford University, Stanford, CA, USA.
Erin SoonDepartment of Pathology, Stanford University, Stanford, CA, USA.
Michael AngeloDepartment of Pathology, Stanford University, Stanford, CA, USA.
Per MagnusNorwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0002-6427-4735
Stefan JohanssonDepartment of Clinical Science, Mohn Center for Diabetes Precision Medicine, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0002-2298-7008
Pål R NjølstadDepartment of Clinical Science, Mohn Center for Diabetes Precision Medicine, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0003-0304-6728
Artem KimDepartment of Population and Public Health Science, Center for Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Steven GazalDepartment of Population and Public Health Science, Center for Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4510-5730
Marc VaudelDepartment of Clinical Science, Mohn Center for Diabetes Precision Medicine, University of Bergen, Bergen, Norway. marc.vaudel@uib.no.ORCID http://orcid.org/0000-0003-1179-9578
Chang April ShuDepartment of Population and Public Health Science, Center for Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA. april.shu@med.usc.edu.ORCID http://orcid.org/0000-0002-3730-5102
Nicholas MancusoDepartment of Population and Public Health Science, Center for Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA. nicholas.mancuso@med.usc.edu.ORCID http://orcid.org/0000-0002-9352-5927

Funding

Higher Education Funding Council for England (HEFCE) Higher Education Funding Council for England (HEFCE)RCUK | Medical Research Council (MRC) M009017, MR/X009777/1, MR/X009920/1Wellcome Trust (Wellcome) WT102627Wellcome Trust (Wellcome) WT210561
6 · The paper itself

Abstract

Most pregnancies are affected by nausea and vomiting, but the most severe form-hyperemesis gravidarum-can be life threatening. Here we performed a multi-ancestry genome-wide association study of hyperemesis gravidarum in 10,974 cases and 461,461 controls across European, Asian, African and Latino ancestries. We identified ten associations: four identified previously (GDF15, IGFBP7, PGR and GFRAL) and six additional loci (SLITRK1, SYN3, IGSF11, FSHB, TCF7L2 and CDH9). Downstream analyses revealed GDF15 and TCF7L2 expression primarily in extravillous trophoblasts, with opposing effects for GDF15 between maternal and fetal genotype. Conversely, IGFBP7 and PGR were expressed primarily in maternal spiral arteries, with effects limited to the maternal genome. Selected loci were associated with abnormal pregnancy weight gain, duration, birth weight and pre-eclampsia. Functional studies identified additional associations including antisense IGFBP7-AS1 and protein ACP1. Potential roles for candidate genes in appetite, insulin signaling and brain plasticity provide pathways to explore etiological mechanisms and therapeutic avenues.

Indexed as

Genetic Predisposition to DiseaseHyperemesis GravidarumNauseaPopulation GroupsPregnancy ComplicationsCase-Control StudiesFemaleGenome-Wide Association StudyHumansPregnancy

Identifiers

PMID41981316

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.