ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
Changing trends in epidemiology, care and outcome of ischemic stroke over 25 years: a large population-based study.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundStroke remains one of the leading causes of death and disability worldwide. This population-based study aimed to examine trends in hospitalization, care processes and outcome of ischemic stroke patients in the Veneto Region over a 25-year period.
methodsWe retrospectively analyzed hospital discharge records of Veneto population from 2000 to 2024, estimating hospitalization rates (HRs) for ischemic stroke, key care process indicators, and short-term mortality. Annual percentage changes were calculated to identify trends.
resultsOverall, 176,351 patients were discharged with a primary diagnosis of ischemic stroke, 84,515 were males (47.9%) and 91,836 were females (52.1%). From 2000 to 2024, the age-standardized HR declined from 172.1 to 96.0 per 100,000 inhabitants and 30-day mortality from 18.3% to 10.5%. The use of intravenous thrombolysis and mechanical thrombectomy increased markedly during the study period, reaching 21.1% and 10.0% in 2024, respectively. During the study period, a higher proportion of patients was admitted to neurology wards (from 37.6% to 68.9%) and to hospitals with a Stroke Unit (SU) (from 63.0% to 89.5%). The sex- and age-adjusted odds of 30-day mortality were lower after admission to neurology wards compared to other wards [OR 0.44 (95% CI: 0.43 to 0.46), p < 0.001] and among those admitted to hospitals with a SU compared to those without [OR 0.83 (95% CI: 0.80 to 0.86), p < 0.001].
conclusionFrom 2000 to 2024, the Veneto Region has experienced a significant reduction in HRs and mortality among patients with ischemic stroke, alongside improvements in admission settings and use of revascularization therapies.
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