Evidence map›Paper›PMID 41981280›Full record

ArticleCommunications chemistry2026

Slug-flow microchannel enables efficient and controllable preparation of sensitive protein nanoparticles.

Zhangyi Gao, Yi Zhang, Anning Tan, Pengli Chen, Saier Liu, Min Qiu, Zhenlun Wang, You Ma, Guozhi Qian, Jasper H A Schuurmans and 4 more

Abstract read
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In one paragraph

Article in Communications chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Zhangyi Gao *State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Yi Zhang *State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Anning Tan *State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Pengli ChenState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Saier LiuState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Min QiuState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Zhenlun WangState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
You MaState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Guozhi QianState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Jasper H A SchuurmansFlow Chemistry Group, Van't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Amsterdam, The Netherlands.
Minjing ShangState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Xin JinState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China. jxcindy@sjtu.edu.cn.ORCID http://orcid.org/0000-0003-1779-6407
Timothy NoёlFlow Chemistry Group, Van't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Amsterdam, The Netherlands. t.noel@uva.nl.ORCID http://orcid.org/0000-0002-3107-6927
Yuanhai SuState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China. y.su@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-0718-301X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22178215National Natural Science Foundation of China (National Science Foundation of China) 22578266
6 · The paper itself

Abstract

Microreactors are valued for efficient mixing and precise control in nanoparticle synthesis. However, when encapsulating sensitive proteins and enzymes, conventional fluidic shear causes serious damage and activity loss. Critically, the interplay between mixing performance and shear effects within microreactors remains poorly understood, yet is pivotal for the successful preparation of protein-based nanoparticles. This study applied a gas-liquid slug-flow microchannel to synthesize protein nanostructures and enzyme nanocapsules, compared to the single-phase flow microchannel, microstructured continuous stirred-tank reactor (micro-CSTR), and batch reactor. Mixing, residence time distribution, and shear effects in these reactors were examined via experiments and computational fluid dynamics (CFD) simulations, linking them to the properties of prepared protein nanoparticles. Results show that the slug-flow microchannel provides efficient mixing, narrow residence time distribution, and suitable shear. This combination offers significant advantages for the uniformity of particle size distribution, drug release, enzyme activity, and stability in both the thermodynamically driven self-assembly of nanoparticles and kinetically driven synthesis of nanocapsules. Specifically, for catalase nanocapsules, this strategy achieved a low PDI of 0.165 (vs. 0.3-0.5 in references) and a productivity of 4 g·day

Identifiers

PMID41981280
PMCPMC13265923

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