Evidence map›Paper›PMID 41981267›Full record

Observational studyAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Brain magnetic resonance imaging biomarkers for future frailty; sub-study of FINGER trial.

Johanna Pöyhönen, Hanna-Maria Roitto, Jenni Lehtisalo, Esko Levälahti, Timo Strandberg, Miia Kivipelto, Riitta Antikainen, Hilkka Soininen, Jaakko Tuomilehto, Tiina Laatikainen and 5 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01041989 (Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01041989 naunknown statusnot on this map

Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability

TypeinterventionalSponsorFinnish Institute for Health and WelfareRan2009 to 2025Enrolled1,200ConditionsCognitive Impairment, DementiaArmsNutritional guidance, Exercise, Cognitive training, Reduction of vascular risk factors
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Johanna PöyhönenDepartment of Public Health, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.ORCID 0009-0003-1524-6134
Hanna-Maria RoittoDepartment of Public Health, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
Jenni LehtisaloDepartment of Public Health, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
Esko LevälahtiDepartment of Public Health, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
Timo StrandbergDepartment of Medicine, Clinicum, University of Helsinki, Helsinki, Finland.
Miia KivipeltoDepartment of Public Health, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
Riitta AntikainenCenter for Life Course Health Research/Geriatrics, University of Oulu, Oulu, Finland.
Hilkka SoininenInstitute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.
Jaakko TuomilehtoNational School of Public Health, Madrid, Spain.
Tiina LaatikainenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Alina SolomonInstitute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.
Ruth StephenInstitute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.
Juha RinneTurku University Hospital, Turku, Finland.
Eric WestmanDivision of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.
Tiia NganduDepartment of Public Health, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.

Funding

AlzheimerfondenFORTE 2023-01125,FINGER-PROHjärnfondenKelaNordforsk through funding to NJ-FINGER 119886Region StockholmResearch Council of Finlandstate research funding for Oulu City Hospital and Turku University HospitalStiftelsen Stockholms Sjukhemthe Alzheimer's Research and Prevention Foundationthe Center for Innovative Medicine (CIMED) at Karolinska Institutetthe EU Joint Programme - Neurodegenerative Disease Research (JPND) EURO-FINGERS and Multi-MEMO 357810the Finnish Cultural Foundationthe Juho Vainio Foundation 202400017the Juho Vainio Foundation FINGERtrialthe Ministry of Education and Culturethe Päivikki and Sakari Sohlberg Foundation 240060the Sigrid Jusélius Foundationthe Swedish Research Councilthe Yrjö Jahnsson Foundation 20237690the Yrjö Jahnsson Foundation FINGERtrial
6 · The paper itself

Abstract

introductionBrain magnetic resonance imaging (MRI) biomarkers for dementia exist, but little is known about their association with future frailty. We investigated whether baseline brain MRI findings associate with pre-frailty/frailty over 11 years.

methodsOne hundred twenty participants, aged 60 to 77 years, in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) had baseline MRI data. Frailty status (Fried phenotype) was measured at baseline, and at 2, 7, and 11 years. Risk of future pre-frailty/frailty per one standard deviation or one class greater volume/thickness/Fazekas score in baseline MRI was evaluated.

resultsPre-frailty/frailty was not associated with MRI biomarkers at baseline. Smaller left hippocampal volume was associated with pre-frailty/frailty at 2 (p = 0.042) and 7 years (p = 0.017), and higher load of periventricular white matter hyperintensities (WMHs) at 2 years (p = 0.048), independently of baseline cognition. DISCUSSION: Smaller left hippocampal volume and higher periventricular WMH score in brain MRI may indicate future frailty risk. CLINICAL TRIAL REGISTRATION NUMBER: The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is registered at ClinicalTrials.gov (no. NCT01041989).

Indexed as

BrainFrailtyMagnetic Resonance ImagingAgedBiomarkersCognitive DysfunctionFemaleFinlandHippocampusHumansMaleMiddle AgedMulticenter Studies as TopicRandomized Controlled Trials as TopicWhite MatterBiomarkersbiomarkerdementiafrailtygray matterlongitudinal studymagnetic resonance imagingpre‐frailtywhite matter hyperintensities

Identifiers

PMID41981267
PMCPMC13079061

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.