Evidence map›Paper›PMID 41981182›Full record

ReviewNature reviews. Neurology2026

UK Biobank at 20 - a growing, global resource for dementia research.

Paul M Matthews, Naomi E Allen, Stephanie Debette, Aiden Doherty, Gwenaëlle Douaud, Eugene P Duff, Paul Elliott, Evelynne S Fulda, Anastasia Ilina, Quentin Le Grand and 9 more

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Paul M MatthewsUK Dementia Research Institute Centre, Imperial College London, London, UK. p.matthews@imperial.ac.uk.ORCID http://orcid.org/0000-0002-1619-8328
Naomi E AllenNuffield Department of Population Health, University of Oxford, Oxford, UK.
Stephanie DebetteInstitut du Cerveau (ICM), Paris Brain Institute, INSERM U1127, UMR CNRS 7225 Paris, Sorbonne Université, Assistance Publique des Hôpitaux de Paris, Paris, France.ORCID http://orcid.org/0000-0001-8675-7968
Aiden DohertyNuffield Department of Population Health, University of Oxford, Oxford, UK.
Gwenaëlle DouaudDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1981-391X
Eugene P DuffUK Dementia Research Institute Centre, Imperial College London, London, UK.
Paul ElliottUK Dementia Research Institute Centre, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-7511-5684
Evelynne S FuldaNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5903-131X
Anastasia IlinaUK Dementia Research Institute Centre, Imperial College London, London, UK.ORCID http://orcid.org/0009-0000-1216-2873
Quentin Le GrandUniversity of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR1219, Bordeaux, France.ORCID http://orcid.org/0000-0002-9299-0747
Adam J LewandowskiNuffield Department of Population Health, University of Oxford, Oxford, UK.
Rebecca MahoneyUK Dementia Research Institute at Cardiff, Cardiff, UK.
Karla MillerUniversity of Oxford Centre for Integrative Neuroimaging (OxCIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Cecilia RodriguezUK Dementia Research Institute Centre, Imperial College London, London, UK.
Martin K RutterUK Biobank, Stockport, UK.
Cynthia SandorUK Dementia Research Institute Centre, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-8905-1052
Rebecca SimsDivision of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK.
Stephen M SmithUniversity of Oxford Centre for Integrative Neuroimaging (OxCIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-8166-069X
Chaoyue WangUniversity of Oxford Centre for Integrative Neuroimaging (OxCIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-9402-1563

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

UK Biobank is the world's most comprehensive longitudinal population-based data and biosample resource. Twenty years after UK Biobank was first established, the incidence of dementia among participants is rising and is set to increase rapidly over the next 5-10 years, creating a distinct opportunity for studies of dementia risk and onset. In addition to extensive clinical phenotyping of >500,000 volunteers from across the UK at recruitment and at follow-up time points, UK Biobank includes data from serial lifestyle questionnaires, cognitive testing, multimodal imaging, accelerometry, genomics and other omics that are linked to individual health, cancer and death records. In this Perspective, we discuss how the use of UK Biobank data has enabled the discovery of new interactions between systemic and brain health and illustrate how these data can be used to characterize and identify risk factors, support mechanistic hypotheses and identify new biomarkers that predict the onset and course of dementia and related disorders. We also consider future developments of UK Biobank, including the UK Biobank Brain Health Study, which will build on and leverage the increasing incidence of dementias to advance understanding of these conditions.

Indexed as

Biological Specimen BanksBiomedical ResearchDementiaUK BiobankHumansUnited Kingdom

Identifiers

PMID41981182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.