Evidence map›Paper›PMID 41981110›Full record

ArticleNature metabolism2026

Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis.

Romane Manceau, Celena M Cherian, Danie Majeur, Colin J Miller, Jasper D Fisher, Frédérick Boisjoly, J Beatrice Liston, Jennifer A Bako, Lianna W Wat, Charlotte F Chao and 31 more

Abstract read
In one paragraph

Article in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Neurons run on fat.npj metabolic health and disease · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

41 authors.

Romane Manceau *Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.
Celena M Cherian *Department of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.
Danie Majeur *Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.
Colin J Miller *Department of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.
Jasper D FisherDepartment of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.
Frédérick BoisjolyCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.
J Beatrice ListonDepartment of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.
Jennifer A BakoDepartment of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.
Lianna W WatDepartment of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.
Charlotte F ChaoDepartment of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.
Audrey LabarreCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.
Serena HollmanDepartment of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.
Sanjana PrakashDepartment of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.
Sébastien AudetCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.
Lewis Depaauw-HoltCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.ORCID http://orcid.org/0009-0001-3797-447X
Benjamin RogersCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.
Anthony BossonCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.ORCID http://orcid.org/0009-0002-6937-7597
Puja BiswasDepartment of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.
Joyce J Y XiDepartment of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.
Catrina A S CallowDepartment of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.
Niyoosha YoosefiDepartment of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0001-5878-4264
Neele SchikoraDepartment of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.
Niki ShahrakiDepartment of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.
Yi Han XiaDepartment of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0002-7790-5655
Alisa HuiDepartment of Chemistry, The University of British Columbia, Vancouver, British Columbia, Canada.
Jared VanderZwaagDivision of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.ORCID http://orcid.org/0000-0002-1546-0304
Khalil BouyakdanCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.
Demetra RodarosCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.
Pavel KotchetkovRegenerative Medicine and Neuroscience Programs, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Caroline DaneaultMontreal Heart Institute Research Centre, Montreal, Quebec, Canada.
Ghazal FallahpourDepartment of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.
Martine TetreaultCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.
Marie-Ève TremblayDivision of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.ORCID http://orcid.org/0000-0003-2863-9626
Matthieu RuizMontreal Heart Institute Research Centre, Montreal, Quebec, Canada.
Baptiste LacosteRegenerative Medicine and Neuroscience Programs, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.ORCID http://orcid.org/0000-0002-1922-8801
J Alex ParkerCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.
Ciaran Murphy-RoyalCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0001-7545-593X
Tao HuanDepartment of Chemistry, The University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0001-6295-2435
Stephanie FultonCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.
Elizabeth J Rideout *Department of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada. elizabeth.rideout@ubc.ca.ORCID http://orcid.org/0000-0003-0012-2828
Thierry Alquier *Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada. thierry.alquier@umontreal.ca.ORCID http://orcid.org/0000-0001-8171-802X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipids are essential for neuron development and physiology

Indexed as

Energy MetabolismHomeostasisLipid DropletsNeuronsAnimalsEndoplasmic ReticulumFemaleLipid MetabolismMaleMice

Identifiers

PMID41981110
PMCPMC13218936

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.