Evidence map›Paper›PMID 41981048›Full record

ArticleJournal of exposure science & environmental epidemiology2026

Targeted and non-targeted analyses of per-and polyfluoroalkyl substances in newborn dried blood spots and risk of childhood acute lymphoblastic leukemia.

Veronica M Vieira, Sheng Liu, Libby M Morimoto, Jeremy Koelmel, Natalie R Binczewski, Joseph L Wiemels, Xiaomei Ma, Krystal J Godri Pollitt, Catherine Metayer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of exposure science & environmental epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Veronica M VieiraDepartment of Environmental and Occupational Health, Joe C. Wen School of Population & Public Health, University of California, Irvine, CA, USA. vvieira@uci.edu.
Sheng LiuDepartment of Environmental Health Sciences, Yale University, New Haven, CT, USA.
Libby M MorimotoDivision of Epidemiology, School of Public Health, University of California, Berkeley, CA, USA.
Jeremy KoelmelDepartment of Environmental Health Sciences, Yale University, New Haven, CT, USA.
Natalie R BinczewskiDepartment of Environmental and Occupational Health, Joe C. Wen School of Population & Public Health, University of California, Irvine, CA, USA.
Joseph L WiemelsCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Xiaomei MaDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
Krystal J Godri PollittDepartment of Environmental Health Sciences, Yale University, New Haven, CT, USA.
Catherine MetayerDivision of Epidemiology, School of Public Health, University of California, Berkeley, CA, USA.

Funding

Exposure to per- and polyfluoroalkyl substances (PFAS) and risk of cancer in childrenR01ES032196 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE, VIEIRA, VERONICA M · 2021 to 2023
$1.9M
NIEHS NIH HHS R01 ES032196
6 · The paper itself

Abstract

backgroundPer- and polyfluoroalkyl substances (PFAS) have carcinogenic potential but are understudied in relation to childhood cancers.

objectiveWe examined associations between targeted and non-targeted PFAS measured in newborn dried blood spots (DBS) and the risk of childhood acute lymphoblastic leukemia (ALL) in Los Angeles County, California, accounting for maternal and child characteristics.

methodsALL cases (n = 125) diagnosed before age 18 years during 2000-2015 and controls (n = 219) were selected from a registry-based study using stratified sampling based on birth year and birth address within a PFAS-contaminated water district according to the USEPA Third Unregulated Contaminant Monitoring Rule. We calculated design-based odds ratios (OR) and 95% confidence intervals (CI) for the effect of PFAS exposures, independently and adjusting for other PFAS. We also conducted non-linear and stratified analyses.

resultsOf the 17 PFAS quantified using targeted analysis, perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) had the highest mean concentrations in DBS, with 4690 and 10,307 pg/g dried blood among cases compared to 4245 and 8142 pg/g dried blood among controls, respectively. The highest risks were observed for the 4th exposure quartile compared with the 1st quartile (PFOA OR = 1.56, CI: 0.42, 5.73; PFOS OR = 1.64, CI: 0.44, 6.14). In non-linear statistical analyses of joint PFOA and PFOS exposures adjusted for other detected PFAS, we also found that ALL risk increased with increasing levels of log2-PFOA and log2-PFOS. Non-targeted analysis identified 26 additional PFAS, for which elevated risk of childhood ALL was associated with a doubling of C SIGNIFICANCE: There was some suggestion that high PFOA and PFOS exposures measured at birth, as well as certain PFAS detected by non-targeted approaches, were related to childhood ALL risk. IMPACT STATEMENT: This study of childhood ALL in Los Angeles County, California found increased risk among children with the highest PFOA and PFOS levels measured in neonatal dried blood spots. These risks were stronger among non-Hispanic children, and the greatest risk was observed for joint PFOA and PFOS exposure adjusting for other detected PFAS and maternal/child characteristics. We also observed possible associations with PFAS discovered by non-targeted analysis. Our results highlight the utility of dried blood spots as a matrix for assessing early life exposures as well as the value of hybrid targeted and non-targeted approaches to measure PFAS in health studies.

Indexed as

Childhood leukemiaDried blood spotsEpidemiologyFluoromatchPFAS

Identifiers

PMID41981048
PMCPMC13123734

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.