Evidence map›Paper›PMID 41980981›Full record

ArticleNature communications2026

Early life exposure to N-nitrosamine drives genotoxicity, mutagenesis, and tumorigenesis in DNA repair-deficient mice.

Lindsay B Volk, Monét Norales, Callie Karjane, Joshua J Corrigan, Alper J Alcaraz, Lee J Pribyl, Nicolette A Bugher, Megan Blawas, Isabella Dulski, Einthavy Arunachalam and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Lindsay B VolkDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8472-3836
Monét NoralesDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0009-0002-7426-6170
Callie KarjaneDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Joshua J CorriganDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Alper J AlcarazDepartment of Biology, University of Ottawa, Ottawa, Canada.ORCID http://orcid.org/0000-0002-3213-6805
Lee J PribylDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-0209-7814
Nicolette A BugherDepartment of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-8343-3017
Megan BlawasDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Isabella DulskiDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0009-0006-8986-2740
Einthavy ArunachalamDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nina GubinaDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1706-1451
Emily MichelsenDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0009-0008-1667-1067
Kannammai PichappanDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-9964-2171
Natalya YakimchukDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0009-0000-1620-1825
Matilda SwansonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0009-0004-0769-5543
Duanduan MaDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Stuart S LevineDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-7363-562X
Desiree L PlataDepartment of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-0657-7735
Robert G CroyDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-3498-3311
Leona D SamsonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
John M EssigmannDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Carole L YaukDepartment of Biology, University of Ottawa, Ottawa, Canada.ORCID http://orcid.org/0000-0002-6725-3454
Sebastian E CarrascoLaboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0002-1926-7296
Bevin P EngelwardDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. bevin@mit.edu.ORCID http://orcid.org/0000-0003-4322-3573

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NILES, JACQUIN C · 1985 to 2020
$25.6M
The MIT Superfund Research Program: A Systems Approach for the Protection of Human Health from Hazardous ChemicalsP42ES027707 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Stuart S Levine · 2017 to 2026
$22.2M
TRAINING GRANTS IN ENVIROMENTAL TOXICOLOGYT32ES007020 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1985 to 2024
$13.1M
Cross-Disciplinary Research Training for Veterinary StudentsT35OD033655 · OD · TUFTS UNIVERSITY BOSTON · PI Cheryl A London, Kelly Ann Metcalf Pate · 2022 to 2026
$459k
NCI NIH HHS P30 CA008748NIEHS NIH HHS P30 ES002109NIEHS NIH HHS P42 ES027707NIEHS NIH HHS T32 ES007020NIH HHS T35 OD033655U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) P30-ES002109U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) T32-ES007020
6 · The paper itself

Abstract

N-Nitrosodimethylamine (NDMA) is a probable human carcinogen found in contaminated pharmaceuticals and drinking water, yet the impact of age on NDMA susceptibility remains poorly understood. Using DNA repair-deficient (Aag

Indexed as

CarcinogenesisDimethylnitrosamineDNA RepairMutagenesisAnimalsCarcinogensCell ProliferationDNA AdductsDNA DamageDNA Modification MethylasesDNA Repair EnzymesExcision RepairFemaleLiverMaleMiceCarcinogensDimethylnitrosamineDNA AdductsDNA Modification MethylasesDNA Repair EnzymesMGMT protein, mouseTumor Suppressor Proteins

Identifiers

PMID41980981
PMCPMC13254281

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.