Evidence map›Paper›PMID 41980980›Full record

ArticleNature communications2026

Dysregulation of macrophage lipid metabolism underlies intracellular bacterial neuroinvasion.

Zhou Sha, Kun Yang, Shoupeng Fu, Xiaoyong Tong, Hui Yang, Huiling Fang, Qianqian He, Ning Li, Xinyu Shu, Qi Liu and 13 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Zhou Sha *School of Life Sciences, Chongqing University, Chongqing, China.
Kun Yang *Chongqing Public Health Medical Center, Chongqing, China.
Shoupeng Fu *School of Veterinary Medicine, Jilin University, Changchun, China.
Xiaoyong Tong *School of Pharmaceutical Sciences, Chongqing University, Chongqing, China.
Hui YangSchool of Life Sciences, Chongqing University, Chongqing, China.
Huiling FangSchool of Life Sciences, Chongqing University, Chongqing, China.
Qianqian HeSchool of Life Sciences, Chongqing University, Chongqing, China.
Ning LiCenter of Biomechanics and Bioengineering, Key Laboratory of Microgravity (National Microgravity Laboratory), Beijing Key Laboratory of Engineered Construction and Mechanobiology, Institute of Mechanics, Chinese Academy of Sciences, Beijing, China.
Xinyu ShuCenter of Biomechanics and Bioengineering, Key Laboratory of Microgravity (National Microgravity Laboratory), Beijing Key Laboratory of Engineered Construction and Mechanobiology, Institute of Mechanics, Chinese Academy of Sciences, Beijing, China.
Qi LiuSchool of Life Sciences, Chongqing University, Chongqing, China.
Beibei FuSchool of Life Sciences, Chongqing University, Chongqing, China.
Jin LiuSchool of Pharmaceutical Sciences, Chongqing University, Chongqing, China.
Qian LiDepartment of Clinical Microbiology and Immunology, College of Pharmacy and Laboratory Medicine, Army Medical University (Third Military Medical University), Chongqing, China.ORCID http://orcid.org/0000-0003-2698-7782
Hao ZengNational Engineering Research Center of Immunological, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Army Medical University (Third Military Medical University), Chongqing, China.
Xiaokai ZhangNational Engineering Research Center of Immunological, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Army Medical University (Third Military Medical University), Chongqing, China.ORCID http://orcid.org/0000-0002-7440-9541
Rui YaoDepartment of Pathology, Chongqing Hygeia Hospital, Chongqing, China.
Xushuo ZhangZhejiang Toyouvax Biopharming, Hangzhou, China.
Wenjin GuoSchool of Veterinary Medicine, Jilin University, Changchun, China.
Xuhu MaoDepartment of Clinical Microbiology and Immunology, College of Pharmacy and Laboratory Medicine, Army Medical University (Third Military Medical University), Chongqing, China.ORCID http://orcid.org/0000-0001-6903-9593
Mian LongCenter of Biomechanics and Bioengineering, Key Laboratory of Microgravity (National Microgravity Laboratory), Beijing Key Laboratory of Engineered Construction and Mechanobiology, Institute of Mechanics, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0003-0819-6186
Xiaoyuan LinDepartment of Clinical Microbiology and Immunology, College of Pharmacy and Laboratory Medicine, Army Medical University (Third Military Medical University), Chongqing, China. linxiaoyuan23@163.com.
Quanming ZouNational Engineering Research Center of Immunological, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Army Medical University (Third Military Medical University), Chongqing, China. qmzou2007@163.com.ORCID http://orcid.org/0000-0002-6971-0786
Haibo WuSchool of Life Sciences, Chongqing University, Chongqing, China. hbwu023@cqu.edu.cn.ORCID http://orcid.org/0000-0002-5961-2947

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82422048National Natural Science Foundation of China (National Science Foundation of China) 92369115National Natural Science Foundation of China (National Science Foundation of China) 92469110Natural Science Foundation of Chongqing (Natural Science Foundation of Chongqing Municipality) CSTB2023NSCQMSX0402
6 · The paper itself

Abstract

Acute central nervous system infection is highly lethal, yet the mechanisms by which intracellular bacteria infiltrate the brain remain unclear. Phagocytes are central to host defense, but how infected cells facilitate bacterial access to the brain is poorly defined. In this study, we characterize a CD36

Indexed as

BrainCentral Nervous System InfectionsLipid MetabolismMacrophages3-Hydroxybutyric AcidAnimalsBlood-Brain BarrierCD36 AntigensFatty Acid-Binding ProteinsGlucoseMiceMice, Inbred C57BLPPAR gamma3-Hydroxybutyric AcidCD36 AntigensCd36 protein, mouseFatty Acid-Binding ProteinsGlucosePPAR gamma

Identifiers

PMID41980980
PMCPMC13253848

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.