Evidence map›Paper›PMID 41980965›Full record

ArticleNature communications2026

SpiR is a gut microbial enzyme that drives cholesterol conversion.

Gabriela Arp, Sophia Levy, Angela K Jiang, Keith Dufault-Thompson, Aoshu Zhong, Maggie Grant, Yue Li, Xiaofang Jiang, Brantley Hall

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gabriela Arp *Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, College Park, MD, USA.ORCID 0009-0004-3819-5648
Sophia Levy *Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, College Park, MD, USA.ORCID 0009-0003-8055-3202
Angela K JiangDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, College Park, MD, USA.ORCID 0009-0005-5525-6251
Keith Dufault-ThompsonNational Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Aoshu ZhongDepartment of Biology, Wake Forest University, Winston-Salem, North Carolina, USA.ORCID 0000-0002-5793-3990
Maggie GrantDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, College Park, MD, USA.ORCID 0000-0003-2607-9493
Yue LiCenter for Bioinformatics and Computational Biology, University of Maryland, College Park, College Park, MD, USA.
Xiaofang JiangNational Library of Medicine, National Institutes of Health, Bethesda, MD, USA. xiaofang.jiang@nih.gov.ORCID 0000-0002-0955-8284
Brantley HallDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, College Park, MD, USA. brantley@umd.edu.

Funding

Enzymatic Determinants of Gut Microbial Metabolic BiotransformationsR35GM155208 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI A. Brantley Hall · 2024 to 2026
$1.2M
NIGMS NIH HHS R35 GM155208U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35-GM155208
6 · The paper itself

Abstract

The gut microbiota contributes to cholesterol homeostasis by converting cholesterol into coprostanol, a non-absorbable sterol excreted in the feces. However, the enzymes mediating this process remain poorly defined. Here, we identify spiR, a steroid Δ

Indexed as

Bacterial ProteinsCholesterolEubacteriumGastrointestinal MicrobiomeSteroid IsomerasesHumansOxidation-ReductionPhylogenyBacterial ProteinsCholesterolSteroid Isomerases

Identifiers

PMID41980965
PMCPMC13079761

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.