Evidence map›Paper›PMID 41980949›Full record

ArticleNature communications2026

Loss of TMEM65 in mice causes mitochondrial disease mediated by mitochondrial Ca

Yingfan Zhang, Hailey A Parry, Laura Reyes, Alex Shamoun, Junhui Sun, Chengyu Liu, Danielle Springer, Audrey Noguchi, Sachiko Nakamori, Angel M Aponte and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Intracellular Ionic Remodeling During Fetal Development of Hereditary Cardiomyopathy of the Hamster.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Article
  3. Article
  4. Mitochondrial CaBiomolecules · 2026
    Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yingfan ZhangNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Hailey A ParryNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Laura ReyesNational Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0404-1817
Alex ShamounNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Junhui SunNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Chengyu LiuNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Danielle SpringerNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Audrey NoguchiNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Sachiko NakamoriNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Angel M AponteNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Jeeva MunasingheNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Raul CovianNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Elizabeth MurphyNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Brian GlancyNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. brian.glancy@nih.gov.ORCID http://orcid.org/0000-0002-8571-244X

Funding

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1ZIAHL006221
6 · The paper itself

Abstract

Transmembrane protein 65 (TMEM65) depletion in a patient caused severe mitochondrial encephalomyopathy, highlighting its clinical importance. Recent studies show TMEM65 acts as a mitochondrial Na

Indexed as

CalciumMembrane ProteinsMitochondriaMitochondrial DiseasesMitochondrial ProteinsAnimalsCalcium ChannelsFemaleHumansMaleMiceMice, KnockoutMuscle, SkeletalNeuronsCalciumCalcium ChannelsMcu protein, mouseMembrane ProteinsMitochondrial Proteins

Identifiers

PMID41980949
PMCPMC13254257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.