Evidence map›Paper›PMID 41980804›Full record

ArticleEnvironmental microbiology reports2026

Microbiota Composition Shaped by Seasonal Variation and Environmental Compartments Affects the Abundance of Antimicrobial-Resistant Bacteria in Indonesian Aquaculture.

Hajime Nakatani, Noor Hidhayati, Dien Arista Anggorowati, Aoi Kaji, Kaho Tobioka, Saki Ishiguro, Stephanie Angela Yosiano, Marsiti Apriastini, Khairul Anam, Dwi Susilaningsih and 7 more

Abstract read
In one paragraph

Article in Environmental microbiology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hajime NakataniDepartment of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Nagoya, Japan.ORCID https://orcid.org/0000-0001-6391-6655
Noor HidhayatiResearch Center for Applied Microbiology, Research Organization for Life Sciences and Environment, National Research and Innovation Agency (BRIN), Cibinong, Indonesia.ORCID https://orcid.org/0009-0006-6520-6386
Dien Arista AnggorowatiResearch Center for Marine and Land Bioindustry, National Research and Innovation Agency (BRIN), Pemenang, Indonesia.ORCID https://orcid.org/0000-0001-7113-9032
Aoi KajiDepartment of Life Sciences, Graduate School of Bioresources, Mie University, Tsu, Japan.ORCID https://orcid.org/0009-0002-2982-2027
Kaho TobiokaDepartment of Life Sciences, Graduate School of Bioresources, Mie University, Tsu, Japan.ORCID https://orcid.org/0009-0005-7407-5237
Saki IshiguroDepartment of Life Sciences, Graduate School of Bioresources, Mie University, Tsu, Japan.ORCID https://orcid.org/0009-0001-4597-7259
Stephanie Angela YosianoResearch Center for Applied Microbiology, Research Organization for Life Sciences and Environment, National Research and Innovation Agency (BRIN), Cibinong, Indonesia.ORCID https://orcid.org/0009-0002-6884-7841
Marsiti ApriastiniResearch Center for Applied Microbiology, Research Organization for Life Sciences and Environment, National Research and Innovation Agency (BRIN), Cibinong, Indonesia.ORCID https://orcid.org/0009-0003-2161-0094
Khairul AnamResearch Center for Applied Microbiology, Research Organization for Life Sciences and Environment, National Research and Innovation Agency (BRIN), Cibinong, Indonesia.ORCID https://orcid.org/0000-0001-8485-5097
Dwi SusilaningsihResearch Center for Applied Microbiology, Research Organization for Life Sciences and Environment, National Research and Innovation Agency (BRIN), Cibinong, Indonesia.ORCID https://orcid.org/0000-0002-9225-6905
Koji MitsuiDepartment of Life Sciences, Graduate School of Bioresources, Mie University, Tsu, Japan.ORCID https://orcid.org/0009-0001-5936-3717
Kotone YamamotoDepartment of Life Sciences, Graduate School of Bioresources, Mie University, Tsu, Japan.ORCID https://orcid.org/0009-0004-7164-0379
Sae TanakaDepartment of Life Sciences, Graduate School of Bioresources, Mie University, Tsu, Japan.ORCID https://orcid.org/0009-0009-3069-8933
Idham Sumarto PratamaResearch Center for Marine and Land Bioindustry, National Research and Innovation Agency (BRIN), Pemenang, Indonesia.ORCID https://orcid.org/0000-0002-5032-8640
Asep RidwanudinResearch Center for Applied Zoology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia.ORCID https://orcid.org/0000-0003-1651-9248
Tomoko ArakawaLaLa Product Ltd., Nagoya, Japan.ORCID https://orcid.org/0009-0009-9457-2985
Fumiyoshi OkazakiDepartment of Life Sciences, Graduate School of Bioresources, Mie University, Tsu, Japan.ORCID https://orcid.org/0000-0002-9639-0626

Funding

Sumitomo Foundation
6 · The paper itself

Abstract

Antimicrobial use in aquaculture can drive antimicrobial-resistant (AMR) bacteria, but the ecological factors shaping their emergence and persistence across environmental compartments remain unclear. We investigated these factors through laboratory experiments and field surveys in Indonesia. In zebrafish aquaria, oxytetracycline exposure promoted the emergence of resistant bacteria and mainly affected the gut microbiota. In field surveys, gene-based analyses identified tetG- and ribosomal protection protein-associated taxa across sample types. Bacterial community analysis revealed seasonal contrasts: dry-season samples frequently clustered into a "main group" enriched in AMR-associated taxa, whereas wet-season samples showed fewer members and greater heterogeneity. Mapping of resistant taxa indicated higher proportions of resistant bacteria in the main group and during the dry season. The median relative abundance of potential tet-resistant bacteria was higher in the main group than in other samples (3.52% vs. 1.34%) and in the dry season than in the wet season (3.34% vs. 1.80%). Quantitative comparisons among environmental compartments suggested that the gut functions as a primary site for the emergence of AMR bacteria, while water serves as a medium for their accumulation and dispersal. These findings indicate that seasonal variation and compartment-specific microbial structure jointly shape the abundance and distribution of AMR bacteria in aquaculture environments.

Indexed as

Anti-Bacterial AgentsAquacultureBacteriaDrug Resistance, BacterialMicrobiotaAnimalsIndonesiaOxytetracyclineSeasonsAnti-Bacterial AgentsOxytetracyclineantimicrobial resistanceaquacultureIndonesiamicrobial communitytetracycline

Identifiers

PMID41980804
PMCPMC13078929

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.