Evidence map›Paper›PMID 41980769›Full record

ArticleGenes & development2026

A dual role for cGAS in shaping cellular and organismal responses to genomic instability.

Marva Bergman, Uri Goshtchevsky, Tehila Atlan, Gwendoline Astre, Ryan Halabi, Hosniyah El Ayoubi, Eitan Moses, Aaron J J Lemus, Bérénice A Benayoun, Yehuda Tzfati and 2 more

Abstract read
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In one paragraph

Article in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marva BergmanDepartment of Genetics, the Silberman Institute, the Hebrew University of Jerusalem, Jerusalem 9103102, Israel.
Uri Goshtchevsky *Department of Genetics, the Silberman Institute, the Hebrew University of Jerusalem, Jerusalem 9103102, Israel.
Tehila Atlan *Department of Genetics, the Silberman Institute, the Hebrew University of Jerusalem, Jerusalem 9103102, Israel.
Gwendoline AstreDepartment of Genetics, the Silberman Institute, the Hebrew University of Jerusalem, Jerusalem 9103102, Israel.
Ryan HalabiDepartment of Genetics, the Silberman Institute, the Hebrew University of Jerusalem, Jerusalem 9103102, Israel.
Hosniyah El AyoubiDepartment of Genetics, the Silberman Institute, the Hebrew University of Jerusalem, Jerusalem 9103102, Israel.
Eitan MosesDepartment of Genetics, the Silberman Institute, the Hebrew University of Jerusalem, Jerusalem 9103102, Israel.
Aaron J J LemusLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.
Bérénice A BenayounLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.ORCID 0000-0002-7401-4777
Yehuda TzfatiDepartment of Genetics, the Silberman Institute, the Hebrew University of Jerusalem, Jerusalem 9103102, Israel.ORCID 0000-0001-7720-435X
Ido Ben-AmiDepartment of Obstetrics and Gynecology, the Eisenberg Research and Development Authority, Sha'are Zedek Medical Center, Faculty of Medicine, the Hebrew University of Jerusalem, Jerusalem 9103102, Israel.
Itamar HarelDepartment of Genetics, the Silberman Institute, the Hebrew University of Jerusalem, Jerusalem 9103102, Israel; itamarh@mail.huji.ac.il.ORCID 0000-0001-9749-8279

Funding

Understanding the regulation and impact of transposable elements in Vertebrate health and diseaseR35GM142395 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BENAYOUN, BERENICE ANATH · 2021 to 2025
$2.2M
Transposable elements as drivers of normal and accelerated aging in VertebratesR21AG063739 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BENAYOUN, BERENICE ANATH · 2019 to 2020
$464k
NIA NIH HHS R21 AG063739NIGMS NIH HHS R35 GM142395
6 · The paper itself

Abstract

Mutations in DNA damage repair (DDR) genes lead to genomic instability, driving a range of degenerative syndromes. In addition to promoting mutation accumulation, unrepaired DNA damage can leak into the cytosol and activate innate immune-sensing pathways, particularly the cGAS-STING axis. However, the extent to which cGAS causally contributes to organismal pathology in DDR syndromes in vivo remains unresolved. Here, we genetically model ataxia telangiectasia (A-T) and Bloom syndrome in the short-lived turquoise killifish (

Indexed as

Cyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseGenomic InstabilityNucleotidyltransferasesAnimalscGAS-STING Signaling PathwayDNA DamageDNA RepairCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseNucleotidyltransferasesataxia telangiectasiacGASDNA damagegenomic instabilitygermlineH3K9me3killifishneuroinflammationsenescence

Identifiers

PMID41980769
PMCPMC13224860

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.