Evidence map›Paper›PMID 41980179›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A Dual-Functional Biohybrid Nanorobot to Synergistically Eradicate Biofilm and Degrade Antibiotic Resistance Genes.

Junzheng Zhang, Tong Dou, Luokai Wang, Jingxian Yang, Wenrui Wang, Shuaitian Guo, Xiangyu Li, Xuefang Huang, Yunlei Xianyu, Dongsheng Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Junzheng ZhangCollege of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China.
Tong DouCollege of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China.ORCID https://orcid.org/0009-0006-2728-018X
Luokai WangCollege of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China.ORCID https://orcid.org/0000-0002-1603-9730
Jingxian YangDivision of Molecular Bacterial Epidemiology & Infectious Diseases, Institute of Veterinary Bacteriology, University of Bern, Bern, Switzerland.
Wenrui WangCollege of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China.
Shuaitian GuoCollege of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China.
Xiangyu LiCollege of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China.
Xuefang HuangInstitute of Biotechnology, Zhejiang University, Hangzhou, China.
Yunlei XianyuDepartment of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID https://orcid.org/0000-0003-1299-3460
Dongsheng WangCollege of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China.ORCID https://orcid.org/0009-0006-1169-2593

Funding

Innovative Team Funding of Zhejiang Province 2023R01004National Key Research and Development Program of China 2022YFC3203800National Natural Science Foundation of China 32302244National Natural Science Foundation of China 52030003National Natural Science Foundation of China 52500260"Pioneer" and "Leading Goose" R&D Program of Zhejiang Province 2025C02124Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study
6 · The paper itself

Abstract

The environmental dissemination of antibiotic-resistant bacteria and associated resistance genes poses a serious threat to public health and ecological safety, while persistent biofilms serve as reservoirs and transmission hubs for antibiotic resistance genes (ARGs). Current strategies are unable to synergistically eradicate biofilm and degrade ARGs. Here, we developed a dual-functional biohybrid nanorobot that integrates the lytic bacteriophage (N4) with Pd nanozymes to eradicate multidrug-resistant Escherichia coli NDM-1 biofilms and degrade released ARGs. Phage N4 enables targeted bacterial lysis and precise delivery of Pd nanozymes, which catalyze the production of reactive oxygen species to enhance antibacterial activity, disrupt biofilm structure, and degrade liberated plasmid-encoded bla

Indexed as

BiofilmsDrug Resistance, BacterialDrug Resistance, MicrobialEscherichia coliAnti-Bacterial AgentsBacteriophagesAnti-Bacterial AgentsAntibiotic resistance genesbacteriophagesbiofilm disruptionnanorobotsnanozymes

Identifiers

PMID41980179
PMCPMC13334968

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.