Evidence map›Paper›PMID 41980100›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Epigenetic constraints and enhancer innovation link neuronal plasticity to evolutionary adaptation.

Andrea Millán-Trejo, Carlos Mora-Martínez, Adrián Tarazona-Sánchez, Carla Lloret-Fernández, Rafael Alis, Antonio Jordán-Pla, Arantza Barrios, Nuria Flames

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrea Millán-Trejo *Developmental Neurobiology Unit, Instituto de Biomedicina de Valencia Instituto de Biomedicina de Valencia. Consejo Superior de Investigaciones Científicas, Valencia 46010, Spain.ORCID 0000-0003-0003-0173
Carlos Mora-Martínez *Developmental Neurobiology Unit, Instituto de Biomedicina de Valencia Instituto de Biomedicina de Valencia. Consejo Superior de Investigaciones Científicas, Valencia 46010, Spain.ORCID 0000-0002-0542-2654
Adrián Tarazona-SánchezDevelopmental Neurobiology Unit, Instituto de Biomedicina de Valencia Instituto de Biomedicina de Valencia. Consejo Superior de Investigaciones Científicas, Valencia 46010, Spain.ORCID 0000-0002-7654-9986
Carla Lloret-FernándezDevelopmental Neurobiology Unit, Instituto de Biomedicina de Valencia Instituto de Biomedicina de Valencia. Consejo Superior de Investigaciones Científicas, Valencia 46010, Spain.ORCID 0000-0002-5370-9318
Rafael AlisDevelopmental Neurobiology Unit, Instituto de Biomedicina de Valencia Instituto de Biomedicina de Valencia. Consejo Superior de Investigaciones Científicas, Valencia 46010, Spain.
Antonio Jordán-PlaDevelopmental Neurobiology Unit, Instituto de Biomedicina de Valencia Instituto de Biomedicina de Valencia. Consejo Superior de Investigaciones Científicas, Valencia 46010, Spain.
Arantza BarriosDepartment of Cell and Developmental Biology, University College London, London WC1E 7JE, United Kingdom.
Nuria FlamesDevelopmental Neurobiology Unit, Instituto de Biomedicina de Valencia Instituto de Biomedicina de Valencia. Consejo Superior de Investigaciones Científicas, Valencia 46010, Spain.ORCID 0000-0003-0961-0609

Funding

EC | Horizon Europe | Excellent Science | HORIZON EUROPE European Research Council (ERC) ERC-Co 101002203- NEUROCODEMinisterio ciencia, innovacion y universidades PID2020-115635RB-I00
6 · The paper itself

Abstract

How nervous systems balance the generation of robust neuron types with gene expression plasticity mechanisms and how these processes impact cell-type evolution are unknown. Here, we use

Indexed as

Adaptation, PhysiologicalBiological EvolutionCaenorhabditis elegansEnhancer Elements, GeneticEpigenesis, GeneticNeuronal PlasticityAnimalsCaenorhabditis elegans ProteinsHistonesMotor NeuronsSerotoninCaenorhabditis elegans ProteinsHistonesSerotoninCaenorhabditisdevelopmental robustnessevolution of neuron typesgene expression plasticitygene regulatory networks

Identifiers

PMID41980100
PMCPMC13099564

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.