Evidence map›Paper›PMID 41980099›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Selective octopaminergic tuning of mushroom body circuits during memory formation.

Ulrike S Franke, Alexandra Großjohann, Samantha Aurich, Ines Köhler, Marius Lamberty, Sara Granato, Alice Fallaha, Jana Breitfeld, Peter Kovacs, Mareike Selcho and 3 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Octopamine receptors inFrontiers in molecular neuroscience · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ulrike S Franke *Department of Animal Physiology, Institute of Biology, Leipzig University, Leipzig 04103, Germany.
Alexandra Großjohann *Department of Genetics, Institute of Biology, Leipzig University, Leipzig 04103, Germany.ORCID 0009-0000-0414-443X
Samantha Aurich *Department of Animal Physiology, Institute of Biology, Leipzig University, Leipzig 04103, Germany.ORCID 0009-0001-9584-661X
Ines KöhlerDepartment of Animal Physiology, Institute of Biology, Leipzig University, Leipzig 04103, Germany.
Marius LambertyDepartment of Animal Physiology, Institute of Biology, Leipzig University, Leipzig 04103, Germany.ORCID 0000-0001-9618-6644
Sara GranatoDepartment of Animal Physiology, Institute of Biology, Leipzig University, Leipzig 04103, Germany.ORCID 0009-0001-8893-2958
Alice FallahaDepartment of Animal Physiology, Institute of Biology, Leipzig University, Leipzig 04103, Germany.ORCID 0009-0009-7347-5748
Jana BreitfeldDivision of Endocrinology, Nephrology and Rheumatology, Department of Medicine III, Leipzig University, Leipzig 04103, Germany.
Peter KovacsDivision of Endocrinology, Nephrology and Rheumatology, Department of Medicine III, Leipzig University, Leipzig 04103, Germany.ORCID 0000-0002-0290-5423
Mareike SelchoDepartment of Animal Physiology, Institute of Biology, Leipzig University, Leipzig 04103, Germany.ORCID 0000-0002-6405-2972
Robert J KittelDepartment of Animal Physiology, Institute of Biology, Leipzig University, Leipzig 04103, Germany.ORCID 0000-0002-9199-4826
Andreas S ThumDepartment of Genetics, Institute of Biology, Leipzig University, Leipzig 04103, Germany.ORCID 0000-0002-3830-6596
Dennis PaulsDepartment of Animal Physiology, Institute of Biology, Leipzig University, Leipzig 04103, Germany.ORCID 0000-0001-8330-8120

Funding

Deutsche Forschungsgemeinschaft (DFG) 420900883Deutsche Forschungsgemeinschaft (DFG) 426503586Deutsche Forschungsgemeinschaft (DFG) 426722269Deutsche Forschungsgemeinschaft (DFG) 430156010Deutsche Forschungsgemeinschaft (DFG) 432195391Deutsche Forschungsgemeinschaft (DFG) 441181781Deutsche Forschungsgemeinschaft (DFG) 447465118Deutsche Forschungsgemeinschaft (DFG) 504082293Deutsche Forschungsgemeinschaft (DFG) 531591887Deutsche Forschungsgemeinschaft (DFG) 533765739Deutsche Forschungsgemeinschaft (DFG) 536984147Europäischer Sozialfonds (ESF) 100649752
6 · The paper itself

Abstract

The catecholamines octopamine and tyramine undoubtedly have a major impact on the life of an insect. A wide range of physiological processes and behaviors are regulated by these neurotransmitters/hormones. Octopamine and tyramine act homologous to the adrenergic system of vertebrates, primarily adapting the organism to the given situation, by switching between the states of alertness and rest. Interestingly, higher brain functions like learning and memory are also regulated by octopamine and tyramine. About 30 y ago, initial work in

Indexed as

Drosophila melanogasterMemoryMushroom BodiesOctopamineAnimalsDopaminergic NeuronsDrosophila ProteinsLarvaOptogeneticsTyramineDrosophila ProteinsOctopamineTyraminedopaminelearningmemoryneuromodulationoctopamine

Identifiers

PMID41980099
PMCPMC13099586

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.