Evidence map›Paper›PMID 41980096›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Immune modulation promotes heart regeneration through macrophage and Granulin functions in medaka.

Kaushik Chowdhury, Chia-Lin Huang, I-Ting Lin, Yu-Jen Hung, Khai Lone Lim, Hsing-Wei Liu, Ke-Hsuan Wei, Kai-Chien Yang, Yao-Ming Chang, Ben Shih-Lei Lai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Immune modulation promotes heart regeneration through macrophage and Granulin functions in medaka.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kaushik ChowdhuryInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0001-5359-2458
Chia-Lin HuangInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.
I-Ting LinInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.
Yu-Jen HungInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0001-9302-261X
Khai Lone LimInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0003-0295-330X
Hsing-Wei LiuInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.
Ke-Hsuan WeiInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.
Kai-Chien YangInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.
Yao-Ming ChangInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.
Ben Shih-Lei LaiInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0002-1409-4701

Funding

Career Development Award, Academia Sinica AS-CDA-112-L04Clinical Research Collaboration Grant from the Institute of Biomedical Sciences, Academia Sinica IBMS-CRC108-P01 IBMS-CRC111-P01Grand Challenge Project, Academia Sinica AS-GC-110-05Research Project Grant from the National Science and Technology Council in Taiwan MOST 108-2320-B-001-032-MY2
6 · The paper itself

Abstract

Myocardial infarction results in irreversible cardiomyocyte loss and fibrotic remodeling in adult mammals, whereas some vertebrates retain the ability to regenerate cardiac tissue. Comparative studies suggest that immune responses critically influence repair outcomes, yet the immune programs associated with regeneration remain incompletely defined. Here, we investigate how immune modulation accelerates cardiac repair in the nonregenerative medaka (

Indexed as

GranulinsHeartMacrophagesOryziasRegenerationAnimalsCell ProliferationMyocardial InfarctionMyocardiumMyocytes, CardiacGranulinscardiac regenerationgranulininflammationmacrophage polarization and phagocytosismyocardial infarction

Identifiers

PMID41980096
PMCPMC13099641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.