ArticleThe European journal of neuroscience2025
Prelimbic Cortex Activity Predicts Anxiety-Like Behavior in the Elevated Plus Maze.
Article in The European journal of neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Auditory conditioned fear elicits anxiety-like behavior and differential neuronal remodeling in the prelimbic and infralimbic cortex of rats.Brain structure & function · 2026Article
- Distinct ensembles in the prelimbic cortex track different measures of motivation for cocaine and water reinforcers.bioRxiv : the preprint server for biology · 2026Article
- A shared ensemble in the prelimbic cortex links impulsivity and anxiety-like behavior.bioRxiv : the preprint server for biology · 2025Article
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Abstract
The medial prefrontal cortex plays a critical role in emotional regulation, and its dysregulation is linked to anxiety disorders. In particular, the prelimbic cortex of the medial prefrontal cortex is thought to modulate anxiety-related behaviors, though its precise role remains debated. Here, we used endoscopic in vivo calcium imaging to assess prelimbic neuronal activity in male and female Sprague-Dawley rats performing in the Elevated Plus Maze, a widely used task to measure anxiety-like behavior. We found that animals that spent less time in the open arms exhibited higher prelimbic activity in the open arms, suggesting that heightened prelimbic activity may reflect greater anxiety or increased avoidance behavior. These results suggest that the prelimbic cortex may play a role in regulating the emotional response to anxiety-provoking situations, potentially influencing the tolerance for exposure to threatening environments.
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