Evidence map›Paper›PMID 41979900›Full record

ArticleJournal of virology2026

Infectious bronchitis virus accessory protein 3a induces renal inflammatory injury by activating the NLRP3 inflammasome via ER calcium mobilization and mitochondrial ROS production.

Min Huang, Chengyin Liukang, Huiming Yang, Lu Sun, Lihua Tang, Pinyi Lv, Feixuan Hou, Ye Zhao, Guozhong Zhang, Jing Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Min HuangState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Chengyin LiukangState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Huiming YangState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Lu SunState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Lihua TangState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Pinyi LvState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Feixuan HouState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Ye ZhaoState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Guozhong ZhangState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.ORCID 0000-0002-8200-312X
Jing ZhaoState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.ORCID 0009-0006-1985-4809

Funding

2115 Talent Development Program of China Agricultural UniversityNational Natural Science Foundation of China 32272986
6 · The paper itself

Abstract

Infectious bronchitis virus (IBV) causes severe renal injury in chickens. Previous work showed that IBV promotes renal pathology by activating the NLRP3 (NOD-like receptor family pyrin domain-containing 3)-Caspase-1IL-1β (interleukin-1 beta) axis in collecting duct epithelial cells. Here, we identify viral determinants and upstream signaling pathways that drive this response. We find that the accessory protein 3a interacts with NLRP3, promotes its oligomerization and enhances inflammasome assembly, thereby acting as a key effector. We generated a 3a-knockout virus (rSD-Δ3a) and a start codon substitution mutant (rSD-3a-GTG) and rescued these recombinant viruses. Compared with the parental rSD strain, these mutants reduced Caspase-1 activity and IL-1β maturation and release in chicken embryonic kidney (CEK) cells.

Indexed as

CalciumCoronavirus InfectionsEndoplasmic ReticulumInfectious bronchitis virusInflammasomesMitochondriaNLR Family, Pyrin Domain-Containing 3 ProteinReactive Oxygen SpeciesViral ProteinsAnimalsCell LineChickensKidneyCalciumInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinReactive Oxygen SpeciesViral Proteinsaccessory protein 3aER calcium mobilizationinfectious bronchitis virusmitochondrial ROSNLRP3 inflammasome

Identifiers

PMID41979900
PMCPMC13185645

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.