Sociodemographic Risk Factors in Therapy Delays and Associated Increased Mortality Among Colorectal Cancer Patients in the US: Insights from Surveillance, Epidemiology, and End Results Program.

Hassam Ali, Vishali Moond, Dushyant Singh Dahiya, Umar Hayat, Mohammad Bilal, Aasma Shaukat

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Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Hassam AliDepartment of Gastroenterology, ECU Health Medical Center, 2100 Stantonsburg Road, Greenville, NC, 27834, USA. hassamali155@gmail.com.

Vishali MoondDepartment of Gastroenterology, West Virginia University, Morgantown, USA.

Dushyant Singh DahiyaDivision of Gastroenterology, Hepatology & Motility, School of Medicine, The University of Kansas, Kansas City, KS, USA.

Umar HayatDepartment of Internal Medicine, Geisinger Wyoming Valley Medical Center, Wilkis Barre, PA, USA.

Mohammad BilalDivision of Gastroenterology & Hepatology, University of Colorado Anschutz Medical Campus, Aurora, USA.

Aasma ShaukatDivision of Gastroenterology & Hepatology, NYU Langone Medical Center, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe investigated the impact of racial/ethnic disparities in therapy initiation on colorectal cancer (CRC) mortality using Surveillance, Epidemiology, and End Results Program (SEER) database.

methodsAdults aged 18-84 years with CRC were identified. Cox models for 60-month all-cause and cancer-specific mortality were adjusted for demographics, stage, tumor site, income, and rural-urban residence.

resultsTherapy initiation was slower for Hispanics (HR 0.85) and non-Hispanic Black (NHB) patients (HR 0.80) compared with non-Hispanic Whites (p < 0.001). Each additional month of delay was associated with a 3% increase in cancer mortality (p < 0.001). Findings were consistent across diagnosis eras, with no significant race-by-era interaction, and adjustment for socioeconomic and geographic factors resulted in minimal attenuation of racial disparities.

conclusionTreatment delays independently contribute to all-cause and cancer-specific mortality, disproportionately affecting NHB and lower-SES patients.

Indexed as

Colorectal NeoplasmsHealthcare DisparitiesTime-to-TreatmentAdolescentAdultAgedAged, 80 and overBlack or African AmericanFemaleHispanic or LatinoHumansMaleMiddle AgedRisk FactorsSEER ProgramSociodemographic FactorsColorectal neoplasmsEthnic groupsHealth status disparitiesSurvival analysisTime-to-treatment

Identifiers

PMID41979766

DOI10.1007/s10620-026-09897-4

PMCPMC13522012

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