Evidence map›Paper›PMID 41979707›Full record

ArticleMarine biotechnology (New York, N.Y.)2026

Postbiotic Dietary Supplementation with Sonicated Shewanella sp. SpPdp11 Improves Intestinal Status in Juvenile Senegalese Sole (Solea senegalensis).

I M Cerezo, B Delgado-Martín, A J Vizcaíno, A Galafat, F J Alarcón-López, I García de la Banda, A Hernández de Rojas, L Díaz, M C Balebona, S T Tapia-Paniagua and 1 more

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In one paragraph

Article in Marine biotechnology (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

I M CerezoDepartamento de Microbiología, Campus de Excelencia Internacional del Mar (Ceimar), Facultad de Ciencias, Universidad de Málaga, Campus de Teatinos s/n, Málaga, 29071, Spain.
B Delgado-MartínUnidad de Bioinformática, Supercomputing and Bioinnovation Center (SCBI), Universidad de Málaga, C. Severo Ochoa, 34, Málaga, 29590, Spain.
A J VizcaínoDepartamento de Biología y Geología, Campus de Excelencia Internacional del Mar (Ceimar), Universidad de Almeria, La Cañada de San Urbano, Almería, 04120, Spain.
A GalafatDepartamento de Biología y Geología, Campus de Excelencia Internacional del Mar (Ceimar), Universidad de Almeria, La Cañada de San Urbano, Almería, 04120, Spain.
F J Alarcón-LópezDepartamento de Biología y Geología, Campus de Excelencia Internacional del Mar (Ceimar), Universidad de Almeria, La Cañada de San Urbano, Almería, 04120, Spain.
I García de la BandaInstituto Español de Oceanografia, Centro Oceanográfico de Santander, Santander, 39080, Spain.
A Hernández de RojasInstituto Español de Oceanografia, Centro Oceanográfico de Santander, Santander, 39080, Spain.
L DíazUnidad de Bioinformática, Supercomputing and Bioinnovation Center (SCBI), Universidad de Málaga, C. Severo Ochoa, 34, Málaga, 29590, Spain.
M C BalebonaDepartamento de Microbiología, Campus de Excelencia Internacional del Mar (Ceimar), Facultad de Ciencias, Universidad de Málaga, Campus de Teatinos s/n, Málaga, 29071, Spain.
S T Tapia-PaniaguaDepartamento de Microbiología, Campus de Excelencia Internacional del Mar (Ceimar), Facultad de Ciencias, Universidad de Málaga, Campus de Teatinos s/n, Málaga, 29071, Spain. stapia@uma.es.
M A MoriñigoDepartamento de Microbiología, Campus de Excelencia Internacional del Mar (Ceimar), Facultad de Ciencias, Universidad de Málaga, Campus de Teatinos s/n, Málaga, 29071, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of non-viable microbial preparations (postbiotics) is emerging as a safe alternative to probiotics in aquaculture. In this study, we investigated the impact of dietary inclusion of sonicated cells of the marine bacterium Shewanella sp. Pdp11 (SpPdp11) on the intestinal health of juvenile Senegalese sole (Solea senegalensis). Fish were fed a control diet or a diet supplemented with SpPdp11 postbiotic for 45 days, and their intestinal status was assessed using histological, transcriptomic, and microbiota analyses. Postbiotic supplementation improved intestinal morphology by widening villi and reducing lamina propria and epithelial height, suggesting enhanced barrier function. RNA-seq analysis revealed downregulation of inflammatory pathways, including ECM receptor interaction and PPAR signaling, together with activation of bile acid biosynthesis. 16 S rRNA profiling showed a marked shift in microbial composition, with decreased prevalence of opportunistic taxa such as Vibrio and Stenotrophomonas and enrichment of beneficial genera, including Acinetobacter, Pseudomonas, and Malacoplasma. These results provide evidence that marine-derived postbiotics can modulate host physiology and gut microbial communities without the risks associated with live probiotics. Sonicated SpPdp11 represents a promising biotechnological feed additive to support intestinal health, reduce inflammation, and promote sustainable aquaculture practices.

Indexed as

Dietary SupplementsFlatfishesIntestinesProbioticsShewanellaAnimal FeedAnimalsAquacultureGastrointestinal MicrobiomeRNA, Ribosomal, 16SRNA, Ribosomal, 16SAquacultureGut microbiotaInflammationIntestinal healthPostbioticPreventive strategySolea senegalensis

Identifiers

PMID41979707
PMCPMC13079515

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.