Evidence map›Paper›PMID 41979692›Full record

ArticleArchives of women's mental health2026

Maternal prenatal stress and infant temperament at one year: exploring the mediating role of postpartum depression in the French EDEN cohort.

Giulia Muriago, Susana Barbosa, Arthur Descarpentry, Xavier Benarous, Muriel Tafflet, Barbara Heude, Judith van der Waerden

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of women's mental health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giulia MuriagoSocial Epidemiology, Mental Health and Addiction Team (ESSMA), Pierre Louis Institute of Epidemiology and Public Health, INSERM, Sorbonne University, Paris, France.
Susana BarbosaSocial Epidemiology, Mental Health and Addiction Team (ESSMA), Pierre Louis Institute of Epidemiology and Public Health, INSERM, Sorbonne University, Paris, France.
Arthur DescarpentrySocial Epidemiology, Mental Health and Addiction Team (ESSMA), Pierre Louis Institute of Epidemiology and Public Health, INSERM, Sorbonne University, Paris, France.
Xavier BenarousSocial Epidemiology, Mental Health and Addiction Team (ESSMA), Pierre Louis Institute of Epidemiology and Public Health, INSERM, Sorbonne University, Paris, France.
Muriel TaffletObstetric, Perinatal, Paediatric Life Course Epidemiology (OPPaLE), Center for Research in Epidemiology and Statistics, INSERM, INRAE, Paris Cité University and Sorbonne University Paris Nord, Paris, France.
Barbara HeudeObstetric, Perinatal, Paediatric Life Course Epidemiology (OPPaLE), Center for Research in Epidemiology and Statistics, INSERM, INRAE, Paris Cité University and Sorbonne University Paris Nord, Paris, France.
Judith van der WaerdenSocial Epidemiology, Mental Health and Addiction Team (ESSMA), Pierre Louis Institute of Epidemiology and Public Health, INSERM, Sorbonne University, Paris, France. judith.van-der-waerden@inserm.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePrenatal stress affects up to 74% of expectant mothers and has been implicated in shaping early child development. This study aims to examine the associations between both subjective (self-reported) and objective prenatal stress and infant temperament at 12 months of age. Additionally, we investigate whether maternal postpartum depression (PPD) mediates these associations.

methodsWe analyzed data from 1,510 mother-infant dyads in the French EDEN birth cohort. Prenatal stress was assessed using the State Anxiety Inventory (STAI), the Center for Epidemiological Studies Depression Scale (CES-D), and a measure of negative life events (NLEs). Infant temperament at 12 months was measured using the Emotionality Activity Sociability (EAS) questionnaire. Adjusted logistic regression models and mediation analyses were used to assess direct and indirect effects.

resultsPrenatal anxiety was associated with greater infant sociability, while prenatal depression predicted increased emotionality and shyness. Objective stress was related to lower infant activity. Mediation analyses revealed that PPD partially mediated the effects of prenatal depression and anxiety on infant emotionality and shyness, accounting for approximately 32% of the association between prenatal depression and infant emotional temperament. No mediation effect was found for the activity domain, although a small inverse direct association was observed.

conclusionOur findings suggest that maternal prenatal stress influences infant temperament in a trait-specific manner and that PPD plays a mediating role in certain domains. These results highlight the importance of addressing both prenatal and postnatal maternal stress when considering early emotional and behavioral development in children. CLINICAL TRIAL NUMBER: not applicable.

Indexed as

Child DevelopmentDepression, PostpartumMothersPregnancy ComplicationsPrenatal Exposure Delayed EffectsStress, PsychologicalTemperamentAdultAnxietyCohort StudiesFemaleFranceHumansInfantMother-Child RelationsPregnancyInfant developmentPostpartum depressionPrenatal stressTemperament traits

Identifiers

PMID41979692

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.