Evidence map›Paper›PMID 41979674›Full record

ArticlePlant cell reports2026

A NAC transcription factor MdNAC1 enhances cadmium tolerance in apple.

Xiang Wu, Hongliang Li, Xinlong Guo, Ranxin Liu, Yanyan Guo, Tiantian Wang, Dandan Liu, Chunxiang You

Abstract read
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In one paragraph

Article in Plant cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiang Wu *National Key Laboratory of Wheat Improvement, Shandong Collaborative Innovation Center of Fruit & Vegetable Quality and Efficient Production, College of Horticulture Science and Engineering, Shandong Agricultural University, Taian, 271018, Shandong, China.
Hongliang Li *College of Forestry, Shandong Agricultural University, Taian, 271018, Shandong, China.
Xinlong GuoNational Key Laboratory of Wheat Improvement, Shandong Collaborative Innovation Center of Fruit & Vegetable Quality and Efficient Production, College of Horticulture Science and Engineering, Shandong Agricultural University, Taian, 271018, Shandong, China.
Ranxin LiuNational Key Laboratory of Wheat Improvement, Shandong Collaborative Innovation Center of Fruit & Vegetable Quality and Efficient Production, College of Horticulture Science and Engineering, Shandong Agricultural University, Taian, 271018, Shandong, China.
Yanyan GuoNational Key Laboratory of Wheat Improvement, Shandong Collaborative Innovation Center of Fruit & Vegetable Quality and Efficient Production, College of Horticulture Science and Engineering, Shandong Agricultural University, Taian, 271018, Shandong, China.
Tiantian WangNational Key Laboratory of Wheat Improvement, Shandong Collaborative Innovation Center of Fruit & Vegetable Quality and Efficient Production, College of Horticulture Science and Engineering, Shandong Agricultural University, Taian, 271018, Shandong, China.
Dandan LiuSchool of Agriculture, Yunnan University, Kunming, 650091, Yunnan, China. liudandan@ynu.edu.cn.
Chunxiang YouNational Key Laboratory of Wheat Improvement, Shandong Collaborative Innovation Center of Fruit & Vegetable Quality and Efficient Production, College of Horticulture Science and Engineering, Shandong Agricultural University, Taian, 271018, Shandong, China. youchunxiang@126.com.

Funding

the National Key Research and Development Program of China 2022YFD201700the National Natural Science Foundation of China 32372642Yunnan Province Key Projects of Applied Basic Research 202401AS070145
6 · The paper itself

Abstract

key messagePhenotypic, physiological and molecular analyses demonstrate that MdNAC1 enhances plant tolerance to cadmium stress. Cadmium (Cd) is a highly toxic heavy metal that severely impairs the growth and development of crops. NAC transcription factors are key regulators of plant abiotic stress responses, but their roles in apple (Malus domestica) Cd stress responses remain largely unclear. Here, we identified the apple NAC gene MdNAC1, which exhibits elevated transcriptional levels under Cd stress. The increased abundance of MdNAC1 upregulates the expression of antioxidant enzyme genes, thereby significantly enhancing antioxidant enzyme activity in transgenic plants. This in turn lowers reactive oxygen species (ROS) accumulation and alleviates oxidative damage to plant growth and development under cadmium stress. Ectopic expression of MdNAC1 in Arabidopsis reduced Cd accumulation by negatively regulating the expression of Cd uptake and transport genes, thereby enhancing Cd tolerance. Further Quantitative Real-time PCR analysis revealed that the expression of multiple Cd uptake and transport-related genes was suppressed in transgenic apple seedlings to regulate Cd stress resistance. Moreover, MdNAC1 overexpression enhanced biomass and chlorophyll content in transgenic plants under Cd stress. Our findings indicate that MdNAC1 enhances plant tolerance to Cd through multiple mechanisms in both apple and Arabidopsis, including increased antioxidant activity, ROS scavenging, increased biomass production, and regulation of Cd uptake and transport. These findings provide key candidate genes for fruit tree breeding programs and offer novel insights into the regulatory mechanisms mediating Cd stress resistance.

Indexed as

Adaptation, PhysiologicalCadmiumMalusPlant ProteinsTranscription FactorsAntioxidantsArabidopsisChlorophyllGene Expression Regulation, PlantPlants, Genetically ModifiedReactive Oxygen SpeciesStress, PhysiologicalAntioxidantsCadmiumChlorophyllPlant ProteinsReactive Oxygen SpeciesTranscription FactorsAntioxidant enzymeAppleCd stressGene expressionMdNAC1

Identifiers

PMID41979674

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.