In one paragraphArticle in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Liwei QiuResearch Center of Clinical Medicine, Research Center of Gerontology and Longevity, Research Center of Immunology, Department of Rheumatology, Department of Geriatrics, Affiliated Hospital of Nantong University, Nantong University, Nantong, China.ORCID 0000-0001-5768-8684 Chen DongResearch Center of Clinical Medicine, Research Center of Gerontology and Longevity, Research Center of Immunology, Department of Rheumatology, Department of Geriatrics, Affiliated Hospital of Nantong University, Nantong University, Nantong, China.
Rui ZhaoResearch Center of Clinical Medicine, Research Center of Gerontology and Longevity, Research Center of Immunology, Department of Rheumatology, Department of Geriatrics, Affiliated Hospital of Nantong University, Nantong University, Nantong, China.ORCID 0000-0002-5629-738X Huiyuan YeResearch Center of Clinical Medicine, Research Center of Gerontology and Longevity, Research Center of Immunology, Department of Rheumatology, Department of Geriatrics, Affiliated Hospital of Nantong University, Nantong University, Nantong, China.
Jian-Lin GaoResearch Center of Clinical Medicine, Research Center of Gerontology and Longevity, Research Center of Immunology, Department of Rheumatology, Department of Geriatrics, Affiliated Hospital of Nantong University, Nantong University, Nantong, China.ORCID 0000-0001-5419-9076 Yizhi ChenDepartment of Nephrology, Hainan Hospital of Chinese PLA General Hospital, Hainan Province Chen Xiangmei Academician Team Innovation Center for Kidney Diseases Research, Sanya, China.ORCID 0000-0003-1197-1999 Chi SunResearch Center of Clinical Medicine, Research Center of Gerontology and Longevity, Research Center of Immunology, Department of Rheumatology, Department of Geriatrics, Affiliated Hospital of Nantong University, Nantong University, Nantong, China.ORCID 0000-0003-4752-7603 Zhifeng GuResearch Center of Clinical Medicine, Research Center of Gerontology and Longevity, Research Center of Immunology, Department of Rheumatology, Department of Geriatrics, Affiliated Hospital of Nantong University, Nantong University, Nantong, China.
Funding
China Higher Education Institution Industry-University-Research Innovation Fund 2023HT041Jiangsu Funding Program for Excellent Postdoctoral TalentJiangsu Provincial Medical Key Discipline Cultivation Unit JSDW202205Jiangsu Provincial Preventive Medicine Research Project Ym2023112Jiangsu Provincial Research Hospital YJXYY202204National Natural Science Foundation of China 82502178National Natural Science Foundation of China 92574113National Natural Science Foundation of China U23A20470Science and technology Project of Nantong City XNBH00031655
6 · The paper itselfAbstract
Aberrant cell-cell communication (CCC) is a recognized hallmark of aging, yet comprehensive analyses of immune CCC-particularly in the context of healthy aging-remain limited. Using single-cell transcriptomics of PBMCs from centenarians (CEN), their offspring (CO), and elderly controls, we found that immune CCC in controls was characterized by myeloid-derived, self-amplifying SASP signals associated with immunosenescence and effector immune cell (EIC) exhaustion. In contrast, healthy-aging individuals (CEN/CO) exhibited reinforced positive regulatory factor (PRF)-mediated ligand-receptor (LR) interactions, such as IL-15 and IL-18, consistent with enhanced EIC cytotoxicity and immune surveillance. These findings were further supported in an independent longevity cohort. Our results suggest distinct immune CCC reprogramming with age and identify a characteristic immune remodeling pattern in centenarians, providing a framework for understanding healthy aging and exceptional longevity.
Indexed as
AgingCell CommunicationSingle-Cell AnalysisAgedAged, 80 and overFemaleHumansLongevityMalecentenarianimmune communication networksimmune remodelingsingle‐cell transcriptomesuccessful aging
Identifiers
PMID41979395
PMCPMC13078127
What OpenQuestion holds
Textmetadata
LicenceCC BY
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