Evidence map›Paper›PMID 41979382›Full record

ArticleAging cell2026

Clearance of Senescent Cells by BCL

Justine V Devulder, Peter S Fenwick, Ewa Kolosionek, May Al-Sahaf, Patrizia Viola, Raphael Lemaire, Neetu Razdan, Hiromi Kudo, Anthony Sinadinos, Lina Odqvist and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Justine V DevulderNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0001-9958-316X
Peter S FenwickNational Heart and Lung Institute, Imperial College London, London, UK.
Ewa KolosionekBioscience COPD/IPF, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
May Al-SahafImperial College Healthcare NHS Trust, London, UK.
Patrizia ViolaImperial College Healthcare NHS Trust, London, UK.
Raphael LemaireBioscience COPD/IPF, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA.
Neetu RazdanBioscience COPD/IPF, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA.
Hiromi KudoSection for Pathology, Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.
Anthony SinadinosNational Heart and Lung Institute, Imperial College London, London, UK.
Lina OdqvistBioscience COPD/IPF, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Louise E DonnellyNational Heart and Lung Institute, Imperial College London, London, UK.
Peter J BarnesNational Heart and Lung Institute, Imperial College London, London, UK.

Funding

Medical Research Centre
6 · The paper itself

Abstract

Ageing and cellular senescence significantly contribute to the progression of age-related diseases, particularly chronic obstructive pulmonary disease (COPD). Cellular senescence refers to the cessation of cell division in response to stress and damage. While senescent cells remain metabolically active, they secrete pro-inflammatory factors that drive disease progression. Senolytic therapies aim to selectively target and eliminate these senescent cells by inducing their apoptosis. This study examines the senolytic potential of BCL

Indexed as

bcl-X ProteinCellular SenescencePulmonary Disease, Chronic ObstructiveApoptosisCell ProliferationEpithelial CellsFibroblastsHumansProteolysis Targeting Chimerabcl-X ProteinProteolysis Targeting Chimera

Identifiers

PMID41979382
PMCPMC13078126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.