Evidence map›Paper›PMID 41979358›Full record

ArticleAging cell2026

Single-Nucleus RNA Sequencing Reveals Muscle Fiber Cell Heterogeneity During Human Skeletal Muscle Aging.

Caixia Gong, Li Wu, Ange Wang, Nan Hua, Chengfan Qin, Shunmei Huang, Xia Zhang, Yunmei Yang, Jing Chen, Qin Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Caixia GongDepartment of Geriatrics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Li WuDepartment of Geriatrics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Ange WangDepartment of Geriatrics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Nan HuaDepartment of Geriatrics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Chengfan QinDepartment of Geriatrics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.ORCID 0009-0004-7199-3668
Shunmei HuangDepartment of Geriatrics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.ORCID 0000-0003-2997-1073
Xia ZhangDepartment of Geriatrics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Yunmei YangDepartment of Geriatrics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.ORCID 0000-0002-6646-4954
Jing ChenDepartment of Geriatrics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Qin ZhangDepartment of Geriatrics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Funding

National Natural Science Foundation of China 82200665National Natural Science Foundation of China 82271588Zhejiang Provincial Department of Science and Technology 2022C03161
6 · The paper itself

Abstract

Aging impairs skeletal muscle mass and function, but the cell-type-resolved transcriptional states and intercellular signaling changes in human muscle aging remain incompletely mapped. Here, we constructed a single-nucleus RNA sequencing (snRNA-seq) atlas of human vastus lateralis muscle from adult (22-60 years) and elderly (99-101 years) male donors. We identified a comprehensive cellular census and discovered a profound reorganization of the myofiber transcriptional landscape. Aging was characterized by a shift from robust "young" states (MYLK4

Indexed as

AgingCell NucleusMuscle Fibers, SkeletalMuscle, SkeletalSequence Analysis, RNAAdultAgedAged, 80 and overHumansMaleMiddle AgedYoung Adultdenervationfatty infiltrationmuscle fiber typessingle‐nucleus RNA sequencingskeletal muscle aging

Identifiers

PMID41979358
PMCPMC13078129

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.