Evidence map›Paper›PMID 41979323›Full record

ArticleeLife2026

Fear conditioning biases olfactory sensory neuron frequencies across generations.

Clara W Liff, Yasmine R Ayman, Eliza C B Jaeger, Avery Cardeiro, Hudson S Lee, Alexis Kim, Angelica Vina-Abarracin, Dianne-Lee K D Ferguson, Bianca J Marlin

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Clara W LiffMortimer B. Zuckerman Mind Brain and Behavior Institute, Columbia University, New York, United States.ORCID 0000-0002-2132-3613
Yasmine R AymanMortimer B. Zuckerman Mind Brain and Behavior Institute, Columbia University, New York, United States.
Eliza C B JaegerMortimer B. Zuckerman Mind Brain and Behavior Institute, Columbia University, New York, United States.
Avery CardeiroMortimer B. Zuckerman Mind Brain and Behavior Institute, Columbia University, New York, United States.
Hudson S LeeMortimer B. Zuckerman Mind Brain and Behavior Institute, Columbia University, New York, United States.
Alexis KimMortimer B. Zuckerman Mind Brain and Behavior Institute, Columbia University, New York, United States.
Angelica Vina-AbarracinMortimer B. Zuckerman Mind Brain and Behavior Institute, Columbia University, New York, United States.
Dianne-Lee K D FergusonMortimer B. Zuckerman Mind Brain and Behavior Institute, Columbia University, New York, United States.
Bianca J MarlinMortimer B. Zuckerman Mind Brain and Behavior Institute, Columbia University, New York, United States.ORCID 0000-0002-4275-7891

Funding

Neurobiology and Behavior training grantT32MH126036 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wesley B Grueber · 2020 to 2026
$2.5M
Brain and Behavior Research Foundation NARSAD Young Investigator Grant 30380Howard Hughes Medical Institute Freeman Hrabrowski ScholarNIH HHS 1S10OD023587-01NIMH NIH HHS T32MH126036Simons Foundation Simons Society of Fellows Junior Fellowship 524991United Negro College Fund E.E. Just Fellowship CU20-1071
6 · The paper itself

Abstract

The main olfactory epithelium initiates the process of odor encoding. Recent studies have demonstrated intergenerationally inherited changes in the olfactory system in response to fear conditioning, resulting in increases in olfactory sensory neuron frequencies and altered responses to odors. We investigated changes in the cellular composition of the olfactory epithelium in response to an aversive stimulus. Here, we achieve volumetric cellular resolution to demonstrate that olfactory fear conditioning increases the number of odor-encoding neurons in mice that experience odor-shock conditioning (F0),

Indexed as

Conditioning, PsychologicalFearOlfactory MucosaOlfactory Receptor NeuronsAnimalsFemaleMaleMiceMice, Inbred C57BLOdorantsSmellbehaviorfear conditioningiDiscomouseneuroscienceolfactionstem cell

Identifiers

PMID41979323
PMCPMC13078775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.