Trial reportAnnals of cardiac anaesthesia2026
The Effect of Dexmedetomidine on Hemodynamic Response during Double-Lumen Tube Insertion: A Randomized Controlled Trial.
Trial report in Annals of cardiac anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimDouble-lumen tube (DLT) insertion, which is often necessary to isolate the lung in thoracic surgeries, causes a significant and prolonged stress response. This study aims to evaluate the effect of a single preinduction bolus of dexmedetomidine 0.5 mcg/kg on hemodynamic responses to DLT insertion and fiberoptic confirmation. MATERIALS AND
methodsIn this prospective randomized control trial, 60 patients coming for thoracic surgery requiring DLT insertion were recruited. Thirty were assigned to the dexmedetomidine group (A) and 30 to the placebo group (B). Group A received 0.5 mcg/kg dexmedetomidine, and Group B received normal saline over 10 min. Heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were recorded at baseline, after study drug administration, just before intubation, at intubation, and thereafter at regular intervals up to 30 min. Usage of supplementary anesthetics and rescue medications was noted.
resultsPatients in Group A had lower HR after study drug administration (P < 0.001), before intubation (P < 0.001), at intubation (P < 0.001), and at various other time points. Group A had lower SBP (P = 0.049) and DBP (P = 0.005) after study drug administration. Fewer patients in Group A required additional propofol (14 vs. 27) (P < 0.001) and lesser doses (21.3 vs. 41.0 mg) (P = 0.008). Lesser Group A patients required additional fentanyl (15 vs. 21) (P = 0.114). More patients in Group A required ephedrine (P = 0.038). Use of phenylephrine and atropine was comparable in both groups.
conclusionDexmedetomidine worked as an excellent adjuvant to anesthesia, providing good HR control and hemodynamic stability during DLT insertion and fiberoptic bronchoscopy confirmation. It decreases the overall anesthetic requirements and causes minimal side effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.