Evidence map›Paper›PMID 41979224›Full record

GuidelineBJU international2026

Guideline of guidelines: lutetium-177 PSMA radioligand therapy in advanced prostate cancer.

Abdullah Al-Khanaty, David Chen, Jonathan Walbaum, David Hennes, Carlos Delgado, Eoin Dinneen, Renu Eapen, Michael S Hofman, Arun A Azad, Declan G Murphy and 2 more

Abstract readPractice GuidelineReview
In one paragraph

Guideline in BJU international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Abdullah Al-KhanatyDivision of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
David ChenDivision of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Jonathan WalbaumDepartment of Urology, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID 0009-0004-9086-8205
David HennesDivision of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Carlos DelgadoDivision of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Eoin DinneenDivision of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Renu EapenDivision of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Michael S HofmanDepartment of Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID 0000-0001-8622-159X
Arun A AzadSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0001-7350-5622
Declan G MurphyDivision of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID 0000-0002-7500-5899
Nathan LawrentschukDivision of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Marlon PereraDivision of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo synthesise current international guidance on lutetium-177-labelled prostate-specific membrane antigen (

methodsA structured literature overview was conducted. PubMed, EMBASE, and official repositories of major urological, oncological, and nuclear medicine societies were searched from inception to 31 October 2025 for prostate cancer guidelines. National and international guidelines or consensus statements published in English were eligible if they provided explicit recommendations regarding

resultsAll societies except ESMO, which has not yet updated its guidance on PSMA-RLT, endorse

conclusionsInternational guidelines largely converge on patient selection, dosing, and multidisciplinary implementation of PSMA-RLT. Ongoing trials including PSMAfore, PSMAddition, UpFrontPSMA, ENZA-p, and LuTectomy are expected to further define its role in earlier and combination treatment settings.

Indexed as

Glutamate Carboxypeptidase IILutetiumProstatic NeoplasmsProstatic Neoplasms, Castration-ResistantRadioisotopesRadiopharmaceuticalsAntigens, SurfaceHeterocyclic Compounds, 1-RingHumansMaleProstate-Specific AntigenAntigens, SurfaceGlutamate Carboxypeptidase IIHeterocyclic Compounds, 1-RingLutetiumLutetium-177lutetium (177Lu) vipivotide tetraxetanProstate-Specific AntigenRadioisotopesRadiopharmaceuticalslutetium‐177‐labelled prostate‐specific membrane antigenmetastatic castration‐resistant prostate cancerprostate cancerradioligand therapytheranostics

Identifiers

PMID41979224
PMCPMC13458634

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.