ArticleClinical and translational science2026
When Selectivity Increases Uncertainty: Context-Dependent Pharmacology in Antibody Drug Development.
Article in Clinical and translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
As antibody therapeutics become increasingly selective and multi-specific, their pharmacological effects depend more strongly on biological context, creating new uncertainties in drug development. In this perspective, we discuss how context-dependent pharmacology complicates preclinical-to-clinical translation, dose optimization, and rational combination therapy selection for antibody drugs. Recognizing context dependence is essential for realizing the full therapeutic potential of highly selective biologics and for advancing a more predictive, mechanism-informed paradigm in antibody drug development.
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