ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Circadian rest/activity rhythms and change in MRI-derived brain volumes: Differences by age in a cognitively healthy sample.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Accelerometer-Derived Relative Amplitude and Midlife Cognition: A Cross-Sectional Study.medRxiv : the preprint server for health sciences · 2026Article
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14 authors.
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Abstract
introductionCircadian rest/activity rhythms (RARs) change across adulthood, and alterations in RARs have been associated with cognitive decline, Alzheimer's disease (AD), and dementia. Little is known, however, about associations of RARs with subsequent changes in brain structure.
methodsWe investigated cross-sectional and longitudinal associations between RARs from wrist actigraphy and AD-relevant brain volumes from magnetic resonance imaging in cognitively unimpaired adults aged ≥ 50 and whether age moderated these associations.
resultsIn cross-sectional analyses, weaker and more fragmented RARs were associated with smaller medial temporal region volumes. Longitudinally, more regular and less fragmented RARs were associated with better maintenance of amygdala volume over time. Further, associations between RAR fragmentation and global atrophy were strongest among the oldest participants. DISCUSSION: Results link RARs with medial temporal lobe and global brain volumes and indicate that these associations may differ by age. Research is needed on the effects of RAR-focused interventions on brain health.
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