Evidence map›Paper›PMID 41979011›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2026

The policy exposome of dementia: Gaps, opportunities, and research agenda.

Clémence Kieny, Geraldine Marks, Matheo Bourgeois, Survana Alladi, Samer Atshan, Carol Brayne, William Dow, Maria Glymour, David Knapp, Gill Livingston and 10 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Clémence KienyCenter for Primary Care and Public Health (Unisanté), Department of Epidemiology and Health Systems, University of Lausanne, Lausanne, Switzerland.
Geraldine MarksCenter for Primary Care and Public Health (Unisanté), Department of Epidemiology and Health Systems, University of Lausanne, Lausanne, Switzerland.
Matheo BourgeoisCenter for Primary Care and Public Health (Unisanté), Department of Epidemiology and Health Systems, University of Lausanne, Lausanne, Switzerland.
Survana AlladiNational Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
Samer AtshanCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Carol BrayneCambridge Public Health, University of Cambridge, Cambridge, UK.
William DowSchool of Public Health, University of California, Berkeley, California, USA.
Maria GlymourDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
David KnappCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Gill LivingstonDivision of Psychiatry, University College London, London, UK.
Minhaj MahmudEconomic Research and Development Impact Department, Asian Development Bank, Manila, Philippines.
Nathalie MonnetCenter for Primary Care and Public Health (Unisanté), Department of Epidemiology and Health Systems, University of Lausanne, Lausanne, Switzerland.
Irene PapanicolasDepartment of Health Services, Policy and Practice, Center for Health System Sustainability, Brown University School of Public Health, Providence, Rhode Island, USA.
Elizabeth PlattCenter for Public Health Law Research, Temple University Beasley School of Law, Philadelphia, Pennsylvania, USA.
David RehkopfDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California, USA.
Ritu SadanaAgeing and Health Unit, Department of Maternal, Newborn, Child and Adolescent Health and Ageing, WHO, Geneva, Switzerland.
Lindsay WallaceDepartment of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada.
Sebastian WalshCambridge Public Health, University of Cambridge, Cambridge, UK.
McKayla WennerCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Mauricio AvendanoCenter for Primary Care and Public Health (Unisanté), Department of Epidemiology and Health Systems, University of Lausanne, Lausanne, Switzerland.

Funding

Gateway Exposome Coordinating Center (GECC) For AD/ADRD ResearchU24AG088894 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sara Adar, David Michael Keith Knapp · 2024 to 2026
$14.8M
NIA NIH HHS U24 AG088894NIA NIH HHS U24AG088894
6 · The paper itself

Abstract

Government policies targeting key risk factors for cognitive decline are potential levers for preventing or delaying dementia. Policy is therefore a central component of the exposome-the cumulative exposures shaping dementia risk across the life course. While extensive research links individual risk factors to dementia, less attention has been paid to how public policies structure these risks. We introduce the concept of the policy exposome and summarize findings from a structured expert consultation conducted by the Gateway Exposome Coordinating center (GECC) to identify priority policy research domains. We argue that systematic collection and harmonization of policy data across countries and sub-national regions can enable causal research on dementia. We propose a tiered research framework to guide policy data collection, prioritizing education, tobacco and alcohol control, air pollution, and old-age social assistance. Using tobacco control as a case study, we illustrate how policies can be operationalized as exposures linkable to dementia outcomes.

Indexed as

DementiaExposomeHealth PolicyPublic PolicyHumansRisk Factorscausal inferencedementia preventionpolicypolicy surveillanceresearch agenda

Identifiers

PMID41979011
PMCPMC13077446

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.