Evidence map›Paper›PMID 41978956›Full record

ArticleChemistry, an Asian journal2026

Preparation and Characterization of Zein/Salecan Nanocomposite Particles for Enhanced Stability and Bioactivity of Lipophilic Retinoids.

Jie Mei, Chen Li, Yunxing Li, Beizhe Chang, Hang Jiang, Cheng Yang, Bingtian Zhao, To Ngai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry, an Asian journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jie MeiKey Laboratory of Synthetic and Biological Colloids, School of Chemical and Material Engineering, Ministry of Education, Jiangnan University, Wuxi, China.
Chen LiSchool of Chemistry and Environmental Engineering, Yuxi Normal University, Yuxi, China.
Yunxing LiKey Laboratory of Synthetic and Biological Colloids, School of Chemical and Material Engineering, Ministry of Education, Jiangnan University, Wuxi, China.ORCID https://orcid.org/0000-0001-8532-2006
Beizhe ChangKey Laboratory of Synthetic and Biological Colloids, School of Chemical and Material Engineering, Ministry of Education, Jiangnan University, Wuxi, China.
Hang JiangKey Laboratory of Synthetic and Biological Colloids, School of Chemical and Material Engineering, Ministry of Education, Jiangnan University, Wuxi, China.
Cheng YangKey Laboratory of Synthetic and Biological Colloids, School of Chemical and Material Engineering, Ministry of Education, Jiangnan University, Wuxi, China.
Bingtian ZhaoKey Laboratory of Synthetic and Biological Colloids, School of Chemical and Material Engineering, Ministry of Education, Jiangnan University, Wuxi, China.
To NgaiDepartment of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

Funding

National Natural Science Foundation of China 22272064Yunnan Fundamental Research Projects 202501AT070432Yuxi Science and Technology Plan Project YF2024089
6 · The paper itself

Abstract

Retinoids are lipophilic compounds with high biological activity but poor stability and water solubility. Herein, novel zein/salecan (Zein/Sal) nanocomposite particles were fabricated via antisolvent precipitation with polysaccharide coating and used as carriers for hydroxypinacolone retinoate (HPR). The mass ratio of zein to Sal significantly affected particle properties, with a mass ratio of 2:1 yielding a homogeneous spherical morphology and high encapsulation efficiency, while HPR was integrated in an amorphous state. The integration of zein with HPR was due to hydrogen bonding and hydrophobic interactions. The resulting HPR-loaded Zein/Sal nanocomposite particles exhibited good colloidal stability over a wide pH range, under high ionic strength conditions, and during long-term storage. Encapsulation also remarkably improved HPR stability under different temperatures and light irradiation. In vitro assays revealed that the Zein/Sal nanocomposite particles had good biocompatibility, reduced the cytotoxicity of encapsulated HPR, and promoted cellular uptake and migration with the encapsulated HPR. Steady release and improved transdermal delivery of encapsulated HPR were also achieved. These results show that Sal serves as a functional stabilizer, improving both the structural and biological functions of zein nanoparticles, and offering a viable vehicle for the delivery of lipophilic retinoids in food, pharmaceutical, and cosmetic applications.

Indexed as

Drug CarriersNanocompositesRetinoidsZeinAnimalsbeta-GlucansCell SurvivalDrug StabilityHumansHydrophobic and Hydrophilic InteractionsParticle Sizebeta-GlucansDrug CarriersRetinoidssalecanZeindeliveryencapsulationnanocomposite particlesalecanzein

Identifiers

PMID41978956
PMCPMC13077527

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.