Evidence map›Paper›PMID 41978907›Full record

ReviewRegenerative biomaterials2026

Targeting delayed healing tissues: immune reprogramming of adaptive immune cells by biomaterials.

Zhiyun Wu, Fengzhen Meng, Yuming Xiang, Xiaohua Pan, William W Lu, Shaoquan Bian, Fan Pan, Liping Ouyang, Xiaoli Zhao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhiyun WuResearch Center for Human Tissues and Organs Degeneration, Shenzhen Key Laboratory of Marine Biomedical Materials, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Fengzhen MengResearch Center for Human Tissues and Organs Degeneration, Shenzhen Key Laboratory of Marine Biomedical Materials, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Yuming XiangResearch Center for Human Tissues and Organs Degeneration, Shenzhen Key Laboratory of Marine Biomedical Materials, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Xiaohua PanInstitute of Clinical Translation and Regenerative Medicine, People's Hospital of Baoan District, The Second Affiliated Hospital of Shenzhen University, 518101, Shenzhen, China.
William W LuResearch Center for Human Tissues and Organs Degeneration, Shenzhen Key Laboratory of Marine Biomedical Materials, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Shaoquan BianResearch Center for Human Tissues and Organs Degeneration, Shenzhen Key Laboratory of Marine Biomedical Materials, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Fan PanFaculty of Pharmaceutical Sciences, Shenzhen University of Advanced Technology, Shenzhen 518107, China.
Liping OuyangShanghai Key Laboratory of Flexible Medical Robotics, Tongren Hospital, Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200336, China.
Xiaoli ZhaoResearch Center for Human Tissues and Organs Degeneration, Shenzhen Key Laboratory of Marine Biomedical Materials, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The adaptive immune system plays a pivotal role in coordinating tissue regeneration. Effective tissue repair and functional recovery depend on precisely regulating adaptive immune cells, especially T and B lymphocytes, and their dynamic crosstalk with innate immune cells. The immunomodulatory effects of biomaterials on adaptive cells could be realized through their influence on innate immune cells. This presents a promising therapeutic strategy, in which biomaterials can be designed to modulate immune activity toward pro-regenerative pathways and enhance healing. This review summarizes current knowledge on the molecular mechanisms that distinguish efficient acute healing from pathological chronic or delayed repair processes. Special attention is given to how key physicochemical properties of biomaterials influence the behavior of immune cells, with a specific emphasis on modulating adaptive immune responses. Understanding these biomaterial-immune cell interactions would advance the fundamental understanding of immunomodulatory biomaterials and provide a rational framework for designing next-generation biomaterials with optimized properties. This approach would help harness the body's intrinsic immune mechanisms to improve the outcomes of tissue regeneration. Future studies will refine these design principles to accelerate clinical translation.

Indexed as

adaptive immune systembiomaterialsimmune reprogrammingphysicochemicaltissue regeneration

Identifiers

PMID41978907
PMCPMC13070659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.