ReviewClinical pharmacology : advances and applications2026
Chronic Pain in Elderly Patients: Pathophysiology, Pharmacologic and Non-Pharmacologic Therapies, and Interventional Management.
Review in Clinical pharmacology : advances and applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Ageism, ableism, and their associated factors among international undergraduate medical students in China: a cross-sectional study.Frontiers in public health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Chronic pain is a debilitating condition faced among the geriatric population, contributing to reduced mobility, impaired daily function, and increased dependence on healthcare services. This review explores the current landscape of chronic pain in the elderly, providing a comprehensive overview of treatment options, with the goal of exploring more effective, individualized care. Patients and Methods: This narrative review draws on a range of studies and clinical publications accessible through the National Center for Biotechnology Information (NCBI) database. The literature reviewed includes research on the underlying mechanisms, diagnostic challenges, and treatment strategies for chronic pain in older adults. Clinical relevance and practical approaches were explored, where risks and benefits of pharmacologic, non-pharmacologic, and interventional therapies were explored. Results: Chronic pain in the elderly is often undertreated, likely due to unaccounted comorbidities and age-related changes in drug metabolism. While acetaminophen remains the recommended first-line agent, the use of NSAIDs and opioids in this population carries significant risks and demands careful consideration. Adjuvant medications such as SNRIs and gabapentinoids offer additional options for neuropathic pain, but may require dose adjustments or close adverse effect monitoring. Non-pharmacologic interventions-such as physical therapy and cognitive behavioral therapy- often are underutilized despite a strong safety profile and evidence of benefit. In cases refractory to conservative measures, interventional procedures including epidural steroid injections, radiofrequency ablation, and spinal cord stimulation may offer meaningful relief for select patients. Conclusion: Managing chronic pain in older adults requires a thoughtful, individualized approach that balances effectiveness with safety. As the population ages, there is a growing need for more inclusive research, better integration of non-drug therapies, and greater access to interdisciplinary care. Tailoring treatment to individual goals can help improve outcomes and preserve independence and function in this vulnerable group.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.