ArticleMaedica2026
Successful Treatment of Cutaneous Leishmania infantum Infection with Immunocryosurgery after Failure of the Respective Monotherapies.
Article in Maedica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herein, we present a case of cutaneous leishmaniasis successfully treated with a modified immunocryosurgery protocol. A 46-year-old male Caucasian presented with two nodules on the forehead of eight-month duration. He reported an unsuccessful attempt to treat the lesions with a session of cryosurgery elsewhere. During the clinical examination, two adjacent hard mobile nodules that did not infiltrate the underlying tissues were notable. Their diameter was 10 mm and 15 mm, respectively. There were no clinical, laboratory or imaging data in favor of a systemic infection. Histology and polymerase chain reaction (PCR) of the tissue confirmed a Leishmania infantum cutaneous leishmaniasis. Therapy with application of 5% imiquimod cream three times per week was initiated. After seven weeks of treatment and despite the substantial local inflammatory reaction, there was no evidence of clinical resolution of the lesions. Treatment was paused and five weeks later the two nodules had merged into a single lesion measuring 40x25 mm. Treatment with three times per week topical imiquimod was reinstated with scheduled cryosurgery sessions, within the context of a modified immunocryosurgery protocol, i.e., cryosurgery sessions during continuous imiquimod application. The patient was treated for a total period of nine weeks. The treatment comprised topical imiquimod and two cryosurgery sessions (open spray liquid nitrogen, two cycles, 15 seconds each) at weeks 3 and 6. At the end of treatment there was complete clinical remission of the lesion leaving an atrophic scar that significantly improved during follow-up. The patient remained disease free for 24 months. The applied modification of the standard immunocryosurgery protocol (three times per week imiquimod application, multiple cryosurgery sessions) achieved treatment of a L. infantum cutaneous leishmaniasis that was refractory to the respective monotherapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.