Evidence map›Paper›PMID 41978840›Full record

ReviewMaedica2026

Robotic Adrenalectomy for Large Virilizing Adrenal Mass: a Case Report and Literature Review.

Danilo Coco, Silvana Leanza, Luca Sessa, Raffaele Genova, Giancarlo Barranco, Massimo Giuseppe Viola

Abstract readReview
In one paragraph

Review in Maedica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Danilo CocoDepartment of General, Robotic and Oncologic Surgery, Giglio Foundation Hospital Cefalu', Palermo, Italy.
Silvana LeanzaDepartment of General, Robotic and Oncologic Surgery, Giglio Foundation Hospital Cefalu', Palermo, Italy.
Luca SessaDepartment of General, Robotic and Oncologic Surgery, Giglio Foundation Hospital Cefalu', Palermo, Italy.
Raffaele GenovaDepartment of Pathology Anatomy, Giglio Foundation Hospital Cefalu', Palermo, Italy.
Giancarlo BarrancoHead of Department of General, Robotic and Oncologic Surgery, Giglio Foundation Hospital Cefalu', Palermo, Italy.
Massimo Giuseppe ViolaHead of Department of General, Robotic and Oncologic Surgery, G. Panico Hospital, Tricase, Lecce, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Androgen-secreting adrenal tumors are rare causes of virilization in adult women and often raise concerns regarding malignancy, particularly when tumor size exceeds 6 cm. Current guidelines recommend surgical resection in hormonally active adrenal masses, with minimally invasive surgery increasingly adopted in selected cases. Case report: We report the case of a 50-year-old woman presenting with progressive virilization due to a right adrenal mass measuring 10 cm. Hormonal evaluation revealed marked androgen excess, with elevated serum testosterone, androstenedione and dehydroepiandrosterone sulfate levels. Imaging studies showed a well-defined adrenal lesion without radiological signs of local invasion. The patient underwent robot-assisted laparoscopic adrenalectomy (RALA). The postoperative course was uneventful, with complete resolution of virilizing symptoms and normalization of androgen levels. Histopathological examination confirmed a benign androgen-secreting adrenal adenoma. Conclusion: This case demonstrates that robot-assisted laparoscopic adrenalectomy is a safe and effective treatment option for large, hormonally active adrenal tumors in carefully selected patients. Robotic surgery offers the benefits of minimally invasive approaches while maintaining oncological safety, supporting its role in guideline-concordant management of complex adrenal lesions.

Indexed as

adrenal adenomaadrenal massandrogen-secreting tumorclinical guidelineshormonal normalizationminimally invasive surgeryrobotic adrenalectomyvirilization

Identifiers

PMID41978840
PMCPMC13061453

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.