ArticleJournal of inflammation research2026
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Plant-Derived Heterocyclic Compounds: A Promising Review on Natural Remedies for Rheumatoid Arthritis Management and Their Mechanistic Insights in Inflammation and Joint Protection.Basic & clinical pharmacology & toxicology · 2026Review
- Ellagic acid in poultry nutrition: emerging roles in gut health, immunity, and sustainable production.Poultry science · 2026Review
- The Gut-Lung Microbiome Axis in Alveolar Stem Cell Regeneration and Lung Repair.Microorganisms · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Purpose: Methods: This study evaluated the anti-RA effects of KCR ethanol extract in vitro and in vivo using LPS-induced RA fibroblast-like synoviocytes (RAFLS) and inflammatory macrophages (RAW264.7), as well as an adjuvant-induced arthritis (AIA) rat model generated with inactivated Mycobacterium tuberculosis. Mechanisms were explored via network pharmacology, molecular biology, and gut microbiota analysis. Results: KCR extract suppressed TNF-α, IL-1β, and IL-6 expression in LPS-stimulated RAFLS and RAW264.7 cells. It markedly inhibited paw swelling, synovial hyperplasia, and bone destruction in AIA rats, potentially by downregulating TNF-α, IL-1β, and IL-6 in paw tissues and modulating gut microbiota ( Conclusion: Collectively, KCR alleviates joint pathologies in AIA rats by suppressing TNF-α-driven inflammation and modulating gut microbiota, with
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.