Evidence map›Paper›PMID 41978789›Full record

ArticleBrain communications2026

Anterior insular co-activation patterns associated with stress markers in chronic primary pain.

Salome Häuselmann, Anna Wyss, Samantha Weber, Nicolas Gninenko, Cristina Concetti, Eliane Müller, Rupert Bruckmaier, Josef Gross, Nina Bischoff, Chantal Berna and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Salome HäuselmannPsychosomatic Medicine, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID https://orcid.org/0009-0009-4812-9763
Anna WyssPsychosomatic Medicine, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Samantha WeberPsychosomatic Medicine, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID https://orcid.org/0000-0002-2689-2938
Nicolas GninenkoPsychosomatic Medicine, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID https://orcid.org/0000-0001-5091-575X
Cristina ConcettiDepartment of Neurology, Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland.
Eliane MüllerPsychosomatic Medicine, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Rupert BruckmaierVeterinary Physiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.ORCID https://orcid.org/0000-0002-9374-5890
Josef GrossVeterinary Physiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.ORCID https://orcid.org/0000-0002-2578-6076
Nina BischoffPsychosomatic Medicine, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Chantal BernaCenter for Integrative and Complementary Medicine, Department of Anesthesiology, Lausanne University Hospital, 1011 Lausanne, Switzerland.
Martin Grosse HoltforthPsychosomatic Medicine, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Selma AybekDepartment of Neurology, Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic primary pain occurs without an identifiable causal disease and is marked by persistent pain, emotional distress and functional disability. The anterior insular cortex, involved in salience processing and integration of sensory, emotional and cognitive aspects of pain, has been implicated in neural processes linking pain and stress responses. This study investigates whether specific brain state dynamics, using the anterior insula as a seed region, are associated with chronic primary pain and examines their associations with pain- and stress-related measures. Resting-state functional MRI, stress biomarkers (cortisol and alpha-amylase), a pain sensitivity test, as well as subjective measures of stress and pain were collected from patients with chronic primary pain (

Indexed as

brain dynamicschronic primary painco-activation patternsfunctional MRIstress response

Identifiers

PMID41978789
PMCPMC13070617

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.