Evidence map›Paper›PMID 41978707›Full record

ArticleGlobal cardiology science & practice2025

Coagulation biomarkers as prognostic indicators in heart failure: A systematic review and meta-analysis of 14,773 patients.

Ceria Halim, Billy Putra Teruna, Indah Ramadhani Harahap, Eric Teo Fernando, L Brianto Christian Nugroho

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Article in Global cardiology science & practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ceria HalimDepartment of Center of Evidence Based Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Billy Putra TerunaDepartment of Center of Evidence Based Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Indah Ramadhani HarahapDepartment of Center of Evidence Based Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Eric Teo FernandoDepartment of Center of Evidence Based Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
L Brianto Christian NugrohoDepartment of Center of Evidence Based Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION AND

objectivesHeart failure (HF) patients are at risk of developing thrombosis due to low cardiac output, systemic inflammatory response, and endothelial dysfunction. Thromboembolic complications in HF patients most commonly lead to fatal consequences.

methodsThe protocol for this study was registered in PROSPERO with identification number CRD42024532861. We performed random-effects meta-analyses on extracted data of hazard ratios (HR) and odds ratios (OR) using Review Manager 5.4.

resultsTwenty-two studies with a total population of 14,773 patients were included. INR was associated with risk of mortality (per 0.1 increase, univariate HR = 1.17, 95% CI: 1.08-1.28,

conclusionLow-certainty evidence weakly supports the potential of D-dimer as an independent prognostic marker in predicting HF mortality.

Identifiers

PMID41978707
PMCPMC13070239

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